2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-6-methyl-4(3H)-pyrimidinone

Base Information

• Chemical Name: 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-6-methyl-4(3H)-pyrimidinone
• CAS No.: 119730-10-8
• Molecular Formula: C₁₃H₁₁ClN₂O₂S
• Molecular Weight: 294.762
• Mol file: 119730-10-8.mol

Synonyms:2-((2-(4-chlorophenyl)-2-oxoethyl)thio)-6-methylpyrimidin-4(3H)-one

Chemical Property of 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-6-methyl-4(3H)-pyrimidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-6-methyl-4(3H)-pyrimidinone

There total 4 articles about 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-6-methyl-4(3H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.85%

6-methyl-2-thiouracil (56-04-2,91795-77-6) → 2-((2-(4-chlorophenyl)-2-oxoethyl)thio)-6-methylpyrimidin-4(3H)-one (119730-10-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1007/s00044-015-1481-y

Reference yield: 80.0%

2-mercapto-6-methylpyrimidin-4(3H)-one (56-04-2) + p-chlorophenacyl chloride (937-20-2) → 2-((2-(4-chlorophenyl)-2-oxoethyl)thio)-6-methylpyrimidin-4(3H)-one (119730-10-8)

Guidance literature:

With sodium hydroxide; In ethanol; for 0.333333h; Heating;

Reference yield:

6-methyl-2-thiouracil (56-04-2) + 4-chlorobenzoylmethyl bromide (536-38-9) → 1-(4-chlorophenyl)-2-((4-hydroxy-6-methylpyrimidin-2-yl)thio)ethanone (119730-10-8)

Guidance literature:

With triethylamine; In 1,4-dioxane; for 1h; Sonication; Heating;

DOI:10.3762/bjoc.7.135

upstream raw materials:

2-mercapto-6-methylpyrimidin-4(3H)-one

p-chlorophenacyl chloride

4-chlorobenzoylmethyl bromide

6-methyl-2-thiouracil

Downstream raw materials:

2-(4-chlorobenzoylmethylene)-6-methyl-2,3-dihydropyrimidin-4(1H)-one

3-(4-chlorophenyl)-7-methyl-5H-thiazolo<3,2-a>pyrimidin-5-one

C₁₃H₁₁ClN₂O₂

2-[2-(4-chlorophenyl)-2-hydroxyvinyl]-6-methylpyrimidin-4-ol