{1-[4-benzyloxymethyl-5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-oxazol-2-yl]-2-methyl-propyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{1-[4-benzyloxymethyl-5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-oxazol-2-yl]-2-methyl-propyl}-carbamic acid tert-butyl ester
CAS No.:793727-79-4
Molecular Formula:C₃₀H₃₆BrN₃O₇
Molecular Weight:630.536
Hs Code.:

{1-[4-benzyloxymethyl-5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1<i>H</i>-indol-3-yl)-oxazol-2-yl]-2-methyl-propyl}-carbamic acid <i>tert</i>-butyl ester

Synonyms:{1-[4-benzyloxymethyl-5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-oxazol-2-yl]-2-methyl-propyl}-carbamic acid tert-butyl ester

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Chemical Property of {1-[4-benzyloxymethyl-5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-oxazol-2-yl]-2-methyl-propyl}-carbamic acid tert-butyl ester

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Technology Process of {1-[4-benzyloxymethyl-5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-oxazol-2-yl]-2-methyl-propyl}-carbamic acid tert-butyl ester

There total 6 articles about {1-[4-benzyloxymethyl-5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-oxazol-2-yl]-2-methyl-propyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 496789-40-3
N-MOM-7-bromoisatin

: 496789-39-0
(S)-2-(1-tert-butoxycarbonylamino-2-methyl)propyloxazole-4-methanol benzyl ether

: 793727-79-4
{1-[4-benzyloxymethyl-5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-oxazol-2-yl]-2-methyl-propyl}-carbamic acid tert-butyl ester

Guidance literature:: (S)-2-(1-tert-butoxycarbonylamino-2-methyl)propyloxazole-4-methanol benzyl ether; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

N-MOM-7-bromoisatin; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h;
DOI:10.1021/ja040092i

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 793727-79-4
{1-[4-benzyloxymethyl-5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-oxazol-2-yl]-2-methyl-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 92 percent / EDC*H₂O; HOBt*H₂O; Et₃N / CH₂Cl₂ / 12 h / 25 °C

2.1: 80 percent / Burgess reagent / tetrahydrofuran / 4 h / Heating

3.1: 90 percent / DBU; BrCCl₃ / CH₂Cl₂ / 3 h / 25 °C

4.1: 83 percent / LiBH₄ / ethanol; tetrahydrofuran / 0 - 25 °C

5.1: NaHMDS / tetrahydrofuran / -78 °C

5.2: 72 percent / n-tetrabutylammonium iodide / tetrahydrofuran / 36 h / 25 °C

6.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

6.2: 73 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C

With lithium borohydride; n-butyllithium; Burgess Reagent; Bromotrichloromethane; sodium hexamethyldisilazane; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; hexane; dichloromethane;
DOI:10.1021/ja040092i

Reference yield:

: 158068-97-4
2-<(S)-1--2-methylpropyl>-4-carbomethoxyoxazole

: 793727-79-4
{1-[4-benzyloxymethyl-5-(7-bromo-3-hydroxy-1-methoxymethyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-oxazol-2-yl]-2-methyl-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 83 percent / LiBH₄ / ethanol; tetrahydrofuran / 0 - 25 °C

2.1: NaHMDS / tetrahydrofuran / -78 °C

2.2: 72 percent / n-tetrabutylammonium iodide / tetrahydrofuran / 36 h / 25 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 73 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C

With lithium borohydride; n-butyllithium; sodium hexamethyldisilazane; In tetrahydrofuran; ethanol; hexane;
DOI:10.1021/ja040092i