7-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-7-oxo-heptanoic acid methyl ester

Base Information

Chemical Name:7-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-7-oxo-heptanoic acid methyl ester
CAS No.:125174-05-2
Molecular Formula:C₁₈H₂₅Cl₂NO₃
Molecular Weight:374.307
Hs Code.:

Synonyms:7-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-7-oxo-heptanoic acid methyl ester

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Chemical Property of 7-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-7-oxo-heptanoic acid methyl ester

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Technology Process of 7-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-7-oxo-heptanoic acid methyl ester

There total 6 articles about 7-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-7-oxo-heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38968-78-4
2-(4'-nitro)benzoylcyclohexanone

: 125174-05-2
7-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-7-oxo-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / H₂ / Pd/C / methanol

2: 61 percent / KOH, H₂O / 1.25 h / Heating

3: 87 percent / H₂SO₄

4: 38 percent / acetic acid; tetrahydrofuran / 168 h / 20 °C

5: Et₃N / CH₂Cl₂ / 3 h / 20 °C

6: NaCl / dimethylformamide / 0.08 h / Heating

With potassium hydroxide; sulfuric acid; water; hydrogen; triethylamine; sodium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00166a015

Reference yield:

: 125174-04-1
7-{4-[Bis-(2-methanesulfonyloxy-ethyl)-amino]-phenyl}-7-oxo-heptanoic acid methyl ester

: 125174-05-2
7-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-7-oxo-heptanoic acid methyl ester

Guidance literature:: With sodium chloride; In N,N-dimethyl-formamide; for 0.0833333h; Heating;
DOI:10.1021/jm00166a015

Reference yield:

: 125174-01-8
6-(4-aminobenzoyl)hexanoic acid

: 125174-05-2
7-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-7-oxo-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / H₂SO₄

2: 38 percent / acetic acid; tetrahydrofuran / 168 h / 20 °C

3: Et₃N / CH₂Cl₂ / 3 h / 20 °C

4: NaCl / dimethylformamide / 0.08 h / Heating

With sulfuric acid; triethylamine; sodium chloride; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00166a015