1-(5-(4-bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone

Base Information

Chemical Name:1-(5-(4-bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone
CAS No.:1333471-37-6
Molecular Formula:C₂₅H₂₆BrNO₆
Molecular Weight:516.389
Hs Code.:

Synonyms:1-(5-(4-bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone

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Chemical Property of 1-(5-(4-bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone

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Technology Process of 1-(5-(4-bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone

There total 5 articles about 1-(5-(4-bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1333472-38-0
2-(4-bromo-3,5-dimethoxyphenyl)furan

: 1333472-27-7
N,2-dimethoxy-N-methyl-2-(4-morpholinophenyl)acetamide

: 1333471-37-6
1-(5-(4-bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone

Guidance literature:: 2-(4-bromo-3,5-dimethoxyphenyl)furan; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 0.583333h; Inert atmosphere;

N,2-dimethoxy-N-methyl-2-(4-morpholinophenyl)acetamide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 - 20 ℃; for 2.41667h;

Reference yield:

: 1204-86-0
4-(4-morpholinyl)benzaldehyde

: 1333471-37-6
1-(5-(4-bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / 1,4-dioxane / 18 h

1.2: pH 2

2.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.83 h / Inert atmosphere; Cooling with ice

2.2: 16 h / 20 °C

3.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0.58 h / -78 °C / Inert atmosphere

3.2: 2.42 h / -78 - 20 °C

With 4-methyl-morpholine; potassium hydroxide; lithium diisopropyl amide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; n-heptane; dichloromethane; ethylbenzene;

Reference yield:

: 4-bromo-3,5-dimethoxyaniline

: 1333471-37-6
1-(5-(4-bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(4-morpholinophenyl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / water / Cooling with ice

1.2: 1.27 h

1.3: 1.83 h / -10 °C

2.1: triphenylphosphine; sodium carbonate; tetrabutylammomium bromide / water; tetrahydrofuran / Inert atmosphere

2.2: 17 h / 60 °C / Inert atmosphere

3.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0.58 h / -78 °C / Inert atmosphere

3.2: 2.42 h / -78 - 20 °C

With sulfuric acid; tetrabutylammomium bromide; sodium carbonate; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; water;