4-Methyl-N-[5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-benzenesulfonamide

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Chemical Name:4-Methyl-N-[5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-benzenesulfonamide
CAS No.:215511-66-3
Molecular Formula:C₂₂H₁₈N₄O₅S
Molecular Weight:450.475
Hs Code.:

Synonyms:4-Methyl-N-[5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-benzenesulfonamide

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Chemical Property of 4-Methyl-N-[5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-benzenesulfonamide

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Technology Process of 4-Methyl-N-[5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-benzenesulfonamide

There total 5 articles about 4-Methyl-N-[5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 98-59-9
p-toluenesulfonyl chloride

: 215511-64-1
3-Amino-5-(3-nitro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 215511-66-3
4-Methyl-N-[5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-benzenesulfonamide

Guidance literature:: With pyridine; 1) 0 deg C, 15 min, 2) reflux, 1.5 h;
DOI:10.1016/S0223-5234(98)80048-2

Reference yield:

: 3882-50-6
2-amino-3'-nitro-benzophenone

: 215511-66-3
4-Methyl-N-[5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1) N-methylmorpholine, iBuOCOCl / 1) CH₂Cl₂, 0 deg C, 15 min, 2) CH₂Cl₂, reflux, 20 min, r.t., overnight

2: NH₃, HgCl₂ / tetrahydrofuran / 3 h / 0 °C

3: 64 percent / NH₄OAc / acetic acid / Ambient temperature

4: 97 percent / 33percent HBr / acetic acid / 1) 0 deg C, 10 min, 2) 25 deg C, 30 min

5: 96 percent / pyridine / 1) 0 deg C, 15 min, 2) reflux, 1.5 h

With 4-methyl-morpholine; pyridine; ammonium acetate; ammonia; hydrogen bromide; mercury dichloride; isobutyl chloroformate; In tetrahydrofuran; acetic acid;
DOI:10.1016/S0223-5234(98)80048-2

Reference yield:

: 215511-62-9
[5-(3-Nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester

: 215511-66-3
4-Methyl-N-[5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / 33percent HBr / acetic acid / 1) 0 deg C, 10 min, 2) 25 deg C, 30 min

2: 96 percent / pyridine / 1) 0 deg C, 15 min, 2) reflux, 1.5 h

With pyridine; hydrogen bromide; In acetic acid;
DOI:10.1016/S0223-5234(98)80048-2