(2E,4E)-5-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-penta-2,4-dienenitrile

Base Information

Chemical Name:(2E,4E)-5-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-penta-2,4-dienenitrile
CAS No.:421558-47-6
Molecular Formula:C₂₂H₁₈N₂O₂
Molecular Weight:342.397
Hs Code.:

Synonyms:(2E,4E)-5-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-penta-2,4-dienenitrile

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Chemical Property of (2E,4E)-5-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-penta-2,4-dienenitrile

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Technology Process of (2E,4E)-5-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-penta-2,4-dienenitrile

There total 4 articles about (2E,4E)-5-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-penta-2,4-dienenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 250603-08-8
2-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzaldehyde

: 421558-47-6
(2E,4E)-5-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-penta-2,4-dienenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran / 0.25 h

1.2: tetrahydrofuran / 20 °C

2.1: DIBAL-H / toluene; CH₂Cl₂

3.1: MnO₂ / CH₂Cl₂ / 20 °C

4.1: NaH / tetrahydrofuran / 0.25 h

4.2: tetrahydrofuran

With manganese(IV) oxide; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; toluene; 1.2: Horner-Emmons reaction;
DOI:10.1248/cpb.50.100

Reference yield:

: 178238-79-4
(E)-3-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-prop-2-en-1-ol

: 421558-47-6
(2E,4E)-5-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-penta-2,4-dienenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: MnO₂ / CH₂Cl₂ / 20 °C

2.1: NaH / tetrahydrofuran / 0.25 h

2.2: tetrahydrofuran

With manganese(IV) oxide; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.50.100

Reference yield:

: (E)-3-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-acrylic acid ethyl ester

: 421558-47-6
(2E,4E)-5-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-penta-2,4-dienenitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: DIBAL-H / toluene; CH₂Cl₂

2.1: MnO₂ / CH₂Cl₂ / 20 °C

3.1: NaH / tetrahydrofuran / 0.25 h

3.2: tetrahydrofuran

With manganese(IV) oxide; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1248/cpb.50.100