methyl 3-[(2-tert-butoxy-2-oxo-1-phenylethyl)sulfamoyl] benzoate

Base Information

• Chemical Name: methyl 3-[(2-tert-butoxy-2-oxo-1-phenylethyl)sulfamoyl] benzoate
• CAS No.: 1611455-10-7
• Molecular Formula: C₂₀H₂₃NO₆S
• Molecular Weight: 405.472
• Mol file: 1611455-10-7.mol

Synonyms:methyl 3-[(2-tert-butoxy-2-oxo-1-phenylethyl)sulfamoyl] benzoate

Chemical Property of methyl 3-[(2-tert-butoxy-2-oxo-1-phenylethyl)sulfamoyl] benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-[(2-tert-butoxy-2-oxo-1-phenylethyl)sulfamoyl] benzoate

There total 2 articles about methyl 3-[(2-tert-butoxy-2-oxo-1-phenylethyl)sulfamoyl] benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

methyl 3-chlorosulfonylbenzoate (63555-50-0) + 2-aminophenylacetic acid tert-butyl ester (53934-78-4,65715-93-7,67672-72-4,124619-74-5) → methyl 3-[(2-tert-butoxy-2-oxo-1-phenylethyl)sulfamoyl] benzoate (1611455-10-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

phenylglycin (2835-06-5) → methyl 3-[(2-tert-butoxy-2-oxo-1-phenylethyl)sulfamoyl] benzoate (1611455-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid / 1,4-dioxane / -78 °C

1.2: 48 h / 20 °C / Sealed tube

2.1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C

With sulfuric acid; triethylamine; In tetrahydrofuran; 1,4-dioxane;

Reference yield: 57.0%

methyl 3-[(2-tert-butoxy-2-oxo-1-phenylethyl)sulfamoyl] benzoate (1611455-10-7) → 3-[(2-tert-butoxy-2-oxo-1-phenyl-ethyl)sulfamoyl] benzoic acid (1611455-11-8)

Guidance literature:

With methanol; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 18h;

upstream raw materials:

methyl 3-chlorosulfonylbenzoate

2-aminophenylacetic acid tert-butyl ester

phenylglycin

Downstream raw materials:

3-[(2-tert-butoxy-2-oxo-1-phenyl-ethyl)sulfamoyl] benzoic acid

[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl] 3-[(2-tert-butoxy-2-oxo-1-phenyl-ethyl)sulfamoyl]benzoate

2-[[3-[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethoxy]carbonylphenyl]sulfonylamino]-2-phenyl-acetic acid

[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxy-ethyl]sulfamoyl]benzoate