2,2-Dimethyl-propionic acid (Z)-(2R,4aR,6S,7R,11aS)-6-[(Z)-3-((4aS,6R,10aR)-7,7-bis-ethylsulfanyl-octahydro-1,5-dioxa-benzocycloocten-6-yl)-allyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-yl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (Z)-(2R,4aR,6S,7R,11aS)-6-[(Z)-3-((4aS,6R,10aR)-7,7-bis-ethylsulfanyl-octahydro-1,5-dioxa-benzocycloocten-6-yl)-allyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-yl ester
CAS No.:221379-82-4
Molecular Formula:C₃₈H₅₆O₇S₂
Molecular Weight:688.99
Hs Code.:

2,2-Dimethyl-propionic acid (Z)-(2R,4aR,6S,7R,11aS)-6-[(Z)-3-((4aS,6R,10aR)-7,7-bis-ethylsulfanyl-octahydro-1,5-dioxa-benzocycloocten-6-yl)-allyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-yl ester

Synonyms:2,2-Dimethyl-propionic acid (Z)-(2R,4aR,6S,7R,11aS)-6-[(Z)-3-((4aS,6R,10aR)-7,7-bis-ethylsulfanyl-octahydro-1,5-dioxa-benzocycloocten-6-yl)-allyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-yl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (Z)-(2R,4aR,6S,7R,11aS)-6-[(Z)-3-((4aS,6R,10aR)-7,7-bis-ethylsulfanyl-octahydro-1,5-dioxa-benzocycloocten-6-yl)-allyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-yl ester

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Technology Process of 2,2-Dimethyl-propionic acid (Z)-(2R,4aR,6S,7R,11aS)-6-[(Z)-3-((4aS,6R,10aR)-7,7-bis-ethylsulfanyl-octahydro-1,5-dioxa-benzocycloocten-6-yl)-allyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-yl ester

There total 36 articles about 2,2-Dimethyl-propionic acid (Z)-(2R,4aR,6S,7R,11aS)-6-[(Z)-3-((4aS,6R,10aR)-7,7-bis-ethylsulfanyl-octahydro-1,5-dioxa-benzocycloocten-6-yl)-allyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (Z)-(3R,4aS,7aR,11aR,12aR)-11a-Ethylsulfanyl-3-phenyl-4a,5,7a,9,10,11,11a,12a-octahydro-1H-2,4,8,12-tetraoxa-dibenzo[a,d]cyclooctene

: 221379-82-4
2,2-Dimethyl-propionic acid (Z)-(2R,4aR,6S,7R,11aS)-6-[(Z)-3-((4aS,6R,10aR)-7,7-bis-ethylsulfanyl-octahydro-1,5-dioxa-benzocycloocten-6-yl)-allyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / Ph₃SnH, AIBN / toluene / 2 h / 110 °C

2: 94 percent / H₂ / 10 percent Pd/C / methanol / 17 h / 25 °C

3: 90 percent / imidazole / CH₂Cl₂ / 0.5 h / 25 °C

4: 89 percent / 4-methylmorpholine N-oxide, tetrapropylammonium perruthenate / CH₂Cl₂; acetonitrile / 0.5 h / 25 °C

5: Zn(OTf)2 / CH₂Cl₂ / 4 h / 25 °C

6: 89 percent / Et₃N, SO₃*pyr / dimethylsulfoxide; CH₂Cl₂ / 0 - 30 °C

7: 1.) HMPA, n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 30 min; 25 deg C, 20 min

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; tetrapropylammonium perruthennate; pyridine-SO₃ complex; 2,2'-azobis(isobutyronitrile); triphenylstannane; hydrogen; zinc trifluoromethanesulfonate; 4-methylmorpholine N-oxide; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile;

Reference yield:

: 193970-59-1
(2R,4S,5R)-4-[(Z)-3-((R)-3,3-Bis-ethylsulfanyl-tetrahydro-pyran-2-yl)-allyl]-2-phenyl-[1,3]dioxan-5-ol

: 221379-82-4
2,2-Dimethyl-propionic acid (Z)-(2R,4aR,6S,7R,11aS)-6-[(Z)-3-((4aS,6R,10aR)-7,7-bis-ethylsulfanyl-octahydro-1,5-dioxa-benzocycloocten-6-yl)-allyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 72 percent / 4 Angstroem molecular sieves, NaHCO₃, AgClO₄, silica gel / nitromethane / 3 h / 25 °C

2: 81 percent / Ph₃SnH, AIBN / toluene / 2 h / 110 °C

3: 94 percent / H₂ / 10 percent Pd/C / methanol / 17 h / 25 °C

4: 90 percent / imidazole / CH₂Cl₂ / 0.5 h / 25 °C

5: 89 percent / 4-methylmorpholine N-oxide, tetrapropylammonium perruthenate / CH₂Cl₂; acetonitrile / 0.5 h / 25 °C

6: Zn(OTf)2 / CH₂Cl₂ / 4 h / 25 °C

7: 89 percent / Et₃N, SO₃*pyr / dimethylsulfoxide; CH₂Cl₂ / 0 - 30 °C

8: 1.) HMPA, n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 30 min; 25 deg C, 20 min

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; tetrapropylammonium perruthennate; pyridine-SO₃ complex; 2,2'-azobis(isobutyronitrile); 4 A molecular sieve; triphenylstannane; hydrogen; silver perchlorate; silica gel; zinc trifluoromethanesulfonate; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; triethylamine; palladium on activated charcoal; In methanol; nitromethane; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile;

Reference yield:

: (Z)-(3R,4aS,7aR,11aS,12aR)-3-Phenyl-4a,5,7a,9,10,11,11a,12a-octahydro-1H-2,4,8,12-tetraoxa-dibenzo[a,d]cyclooctene

: 221379-82-4
2,2-Dimethyl-propionic acid (Z)-(2R,4aR,6S,7R,11aS)-6-[(Z)-3-((4aS,6R,10aR)-7,7-bis-ethylsulfanyl-octahydro-1,5-dioxa-benzocycloocten-6-yl)-allyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / H₂ / 10 percent Pd/C / methanol / 17 h / 25 °C

2: 90 percent / imidazole / CH₂Cl₂ / 0.5 h / 25 °C

3: 89 percent / 4-methylmorpholine N-oxide, tetrapropylammonium perruthenate / CH₂Cl₂; acetonitrile / 0.5 h / 25 °C

4: Zn(OTf)2 / CH₂Cl₂ / 4 h / 25 °C

5: 89 percent / Et₃N, SO₃*pyr / dimethylsulfoxide; CH₂Cl₂ / 0 - 30 °C

6: 1.) HMPA, n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 30 min; 25 deg C, 20 min

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; tetrapropylammonium perruthennate; pyridine-SO₃ complex; hydrogen; zinc trifluoromethanesulfonate; 4-methylmorpholine N-oxide; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;