3,4-Dihydro-2-(2-hydroxyethyl)-4-(4-methoxybenzyl)-3-oxo-2H-1,4-benzoxazine

Base Information

Chemical Name:3,4-Dihydro-2-(2-hydroxyethyl)-4-(4-methoxybenzyl)-3-oxo-2H-1,4-benzoxazine
CAS No.:191096-72-7
Molecular Formula:C₁₈H₁₉NO₄
Molecular Weight:313.353
Hs Code.:

Synonyms:3,4-Dihydro-2-(2-hydroxyethyl)-4-(4-methoxybenzyl)-3-oxo-2H-1,4-benzoxazine

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Chemical Property of 3,4-Dihydro-2-(2-hydroxyethyl)-4-(4-methoxybenzyl)-3-oxo-2H-1,4-benzoxazine

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Technology Process of 3,4-Dihydro-2-(2-hydroxyethyl)-4-(4-methoxybenzyl)-3-oxo-2H-1,4-benzoxazine

There total 6 articles about 3,4-Dihydro-2-(2-hydroxyethyl)-4-(4-methoxybenzyl)-3-oxo-2H-1,4-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 191097-22-0
2-(2-tert-butyldimethylsiloxyethyl)-4H-benzo[1,4]oxazin-3-one

: 191096-72-7
3,4-Dihydro-2-(2-hydroxyethyl)-4-(4-methoxybenzyl)-3-oxo-2H-1,4-benzoxazine

Guidance literature:

Reference yield:

: 88-75-5,78813-12-4
2-hydroxynitrobenzene

: 191096-72-7
3,4-Dihydro-2-(2-hydroxyethyl)-4-(4-methoxybenzyl)-3-oxo-2H-1,4-benzoxazine

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / K₂CO₃ / dimethylformamide / 0 - 20 °C

2: H₂ / Pd/C / ethanol

3: imidazole / dimethylformamide

4: NaH / dimethylformamide

5: aq. CH₃SO₃H / methanol

With 1H-imidazole; methanesulfonic acid; hydrogen; sodium hydride; potassium carbonate; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00401-3

Reference yield:

: 58835-34-0
3-(2-nitrophenoxy)dihydrofuran-2-one

: 191096-72-7
3,4-Dihydro-2-(2-hydroxyethyl)-4-(4-methoxybenzyl)-3-oxo-2H-1,4-benzoxazine

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / ethanol

2: imidazole / dimethylformamide

3: NaH / dimethylformamide

4: aq. CH₃SO₃H / methanol

With 1H-imidazole; methanesulfonic acid; hydrogen; sodium hydride; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00401-3