6-(4-(diethylamino)phenyl)-N,N-diethylphenanthridin-9-amine

Base Information

• Chemical Name: 6-(4-(diethylamino)phenyl)-N,N-diethylphenanthridin-9-amine
• CAS No.: 1402905-36-5
• Molecular Formula: C₂₇H₃₁N₃
• Molecular Weight: 397.563
• Mol file: 1402905-36-5.mol

Synonyms:6-(4-(diethylamino)phenyl)-N,N-diethylphenanthridin-9-amine

Chemical Property of 6-(4-(diethylamino)phenyl)-N,N-diethylphenanthridin-9-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-(diethylamino)phenyl)-N,N-diethylphenanthridin-9-amine

There total 2 articles about 6-(4-(diethylamino)phenyl)-N,N-diethylphenanthridin-9-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C27H32ClN3 (1402905-57-0) → 6-(4-(diethylamino)phenyl)-N,N-diethylphenanthridin-9-amine (1402905-36-5) + 6-(4-(diethylamino)phenyl)-N,N-diethylphenanthridin-8-amine (1402905-37-6)

Guidance literature:

With potassium tert-butylate; ethylene glycol; In toluene; at 120 ℃; for 18h; Overall yield = 98 %; regioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol302489n DOI:10.1021/ol302489n

Reference yield:

4,4'-bis(diethylamino)benzophenone (90-93-7) + o-chloroaniline (95-51-2) → 6-(4-(diethylamino)phenyl)-N,N-diethylphenanthridin-9-amine (1402905-36-5) + 6-(4-(diethylamino)phenyl)-N,N-diethylphenanthridin-8-amine (1402905-37-6)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc(II) chloride / toluene / Reflux; Schlenk technique

2: potassium tert-butylate; ethylene glycol / toluene / 18 h / 120 °C / Inert atmosphere; Schlenk technique

With potassium tert-butylate; ethylene glycol; zinc(II) chloride; In toluene;

DOI:10.1021/ol302489n DOI:10.1021/ol302489n

upstream raw materials:

C₂₇H₃₂ClN₃

4,4'-bis(diethylamino)benzophenone

o-chloroaniline

Refernces

• 1、 Wu, Yinuo,Wong, Shun Man,Mao, Fei,Chan, Tek Long,Kwong, Fuk Yee. "Intramolecular direct C-H bond arylation from aryl chlorides: A transition-metal-free approach for facile access of phenanthridines". supporting information. p. 5306 - 5309. Retrieved 2013/01/15.