5-tert-butyldiphenylsilyloxy-2-hydroxy-2-methyloct-7-yn-1-yl toluene-p-sulphonate

Base Information

Chemical Name:5-tert-butyldiphenylsilyloxy-2-hydroxy-2-methyloct-7-yn-1-yl toluene-p-sulphonate
CAS No.:130284-41-2
Molecular Formula:C₃₂H₄₀O₅SSi
Molecular Weight:564.818
Hs Code.:

Synonyms:5-tert-butyldiphenylsilyloxy-2-hydroxy-2-methyloct-7-yn-1-yl toluene-p-sulphonate

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Chemical Property of 5-tert-butyldiphenylsilyloxy-2-hydroxy-2-methyloct-7-yn-1-yl toluene-p-sulphonate

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Technology Process of 5-tert-butyldiphenylsilyloxy-2-hydroxy-2-methyloct-7-yn-1-yl toluene-p-sulphonate

There total 4 articles about 5-tert-butyldiphenylsilyloxy-2-hydroxy-2-methyloct-7-yn-1-yl toluene-p-sulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 130284-40-1
5-tert-butyldiphenylsilyloxy-2-methyloct-7-yne-1,2-diol

: 98-59-9
p-toluenesulfonyl chloride

: 130284-41-2
5-tert-butyldiphenylsilyloxy-2-hydroxy-2-methyloct-7-yn-1-yl toluene-p-sulphonate

Guidance literature:: With pyridine; for 24h; Ambient temperature;
DOI:10.1016/S0040-4039(00)89021-8

Reference yield:

: 130284-39-8
3-tert-butyldiphenylsilyloxy-1-(2,2,4-trimethyl-1,3-dioxolan-4-yl)hex-5-yne

: 130284-41-2
5-tert-butyldiphenylsilyloxy-2-hydroxy-2-methyloct-7-yn-1-yl toluene-p-sulphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / Amberlite IR 120 / methanol / 36 h

2: 84 percent / pyridine / 22 h / Ambient temperature

With pyridine; Amberlite IR 120; In methanol;

Reference yield:

: 57624-96-1
3-(2,2,4-trimethyl-[1,3]dioxolan-4-yl)-propan-1-ol

: 130284-41-2
5-tert-butyldiphenylsilyloxy-2-hydroxy-2-methyloct-7-yn-1-yl toluene-p-sulphonate

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / (F₃CCO)2O / dimethylsulfoxide; CH₂Cl₂ / 0.25 h / -60 °C

2: 1) Mg, HgCl₂ / 1) diethyl ether, toluene, 0 deg C, 0.5 h, 2) Et₂O, rt, 1 h

3: 96 percent / imidazole / CH₂Cl₂ / 8 h / Ambient temperature

4: 76 percent / Amberlite IR 120 / methanol / 36 h

5: 84 percent / pyridine / 22 h / Ambient temperature

With pyridine; 1H-imidazole; Amberlite IR 120; magnesium; trifluoroacetic anhydride; mercury dichloride; In methanol; dichloromethane; dimethyl sulfoxide;