(rac) 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)propanoic acid

Base Information

Chemical Name:(rac) 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)propanoic acid
CAS No.:1599477-77-6
Molecular Formula:C₂₀H₂₅ClF₃NO₃
Molecular Weight:419.872
Hs Code.:

Synonyms:(rac) 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)propanoic acid

Suppliers and Price of (rac) 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (rac) 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (rac) 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)propanoic acid

There total 6 articles about (rac) 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 468075-00-5
1-bromo-2-chloro-4-(trifluoromethoxy)benzene

: 1599478-98-4
benzyl (1-ethoxy-1-oxopropan-2-ylidene)-3-azaspiro[5.5]undec-7-ene-3-carboxylate

: 1599477-77-6
(rac) 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)propanoic acid

: 1599477-78-7
rac-2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undec-8-en-9-yl)propanoic acid

Guidance literature:: benzyl (1-ethoxy-1-oxopropan-2-ylidene)-3-azaspiro[5.5]undec-7-ene-3-carboxylate; With palladium on activated charcoal; hydrogen; In ethanol; at 80 ℃;

2-bromo-1-chloro-4-(trifluoromethoxy)benzene; With caesium carbonate; In 1,4-dioxane; at 100 ℃; for 24h; Inert atmosphere;

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 50 ℃;

Reference yield:

: 468075-00-5
1-bromo-2-chloro-4-(trifluoromethoxy)benzene

: 1599478-98-4
benzyl (1-ethoxy-1-oxopropan-2-ylidene)-3-azaspiro[5.5]undec-7-ene-3-carboxylate

: 1599477-77-6
(rac) 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)propanoic acid

: C₂₀H₂₃ClF₃NO₃

Guidance literature:: benzyl (1-ethoxy-1-oxopropan-2-ylidene)-3-azaspiro[5.5]undec-7-ene-3-carboxylate; With palladium on activated charcoal; hydrogen; In ethanol; at 80 ℃;

2-bromo-1-chloro-4-(trifluoromethoxy)benzene; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; caesium carbonate; In 1,4-dioxane; at 100 ℃; for 24h; Inert atmosphere;

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 50 ℃;
DOI:10.1021/acsmedchemlett.6b00360

Reference yield:

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 1599477-77-6
(rac) 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)propanoic acid

: C₂₀H₂₃ClF₃NO₃

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / ethanol; water / 1 h / 100 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

2.2: 48 h / 60 °C

3.1: hydrogen; palladium on activated charcoal / ethanol / 80 °C

3.2: 24 h / 100 °C / Inert atmosphere

3.3: 50 °C

With palladium on activated charcoal; hydrogen; sodium hydride; potassium hydroxide; In tetrahydrofuran; ethanol; water; 2.1: |Horner-Wadsworth-Emmons Olefination / 2.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/acsmedchemlett.6b00360