2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3-fluorophenyl)-2-hydroxyethanone

Base Information

Chemical Name:2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3-fluorophenyl)-2-hydroxyethanone
CAS No.:1622219-92-4
Molecular Formula:C₁₆H₁₃F₃O₃
Molecular Weight:310.273
Hs Code.:

Synonyms:2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3-fluorophenyl)-2-hydroxyethanone

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Chemical Property of 2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3-fluorophenyl)-2-hydroxyethanone

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Technology Process of 2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3-fluorophenyl)-2-hydroxyethanone

There total 4 articles about 2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3-fluorophenyl)-2-hydroxyethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1622219-91-3
(4-(difluoromethoxy)-3-methylphenyl)(2-(3-fluorophenyl)-1,3-dithian-2-yl)methanol

: 1622219-92-4
2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3-fluorophenyl)-2-hydroxyethanone

Guidance literature:: With bis-[(trifluoroacetoxy)iodo]benzene; In water; acetonitrile; at 20 ℃; for 0.333333h;

Reference yield:

: 15174-69-3
4-hydroxy-3-methyl-benzaldehyde

: 1622219-92-4
2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3-fluorophenyl)-2-hydroxyethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3.25 h / 95 °C

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

2.2: 1.25 h / -10 - 20 °C

3.1: bis-[(trifluoroacetoxy)iodo]benzene / acetonitrile; water / 0.33 h / 20 °C

With n-butyllithium; potassium carbonate; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 456-48-4
3-Fluorobenzaldehyde

: 1622219-92-4
2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3-fluorophenyl)-2-hydroxyethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

2.2: 1.25 h / -10 - 20 °C

3.1: bis-[(trifluoroacetoxy)iodo]benzene / acetonitrile; water / 0.33 h / 20 °C

With n-butyllithium; boron trifluoride diethyl etherate; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; dichloromethane; water; acetonitrile;