2-[(E,1R)-1-(benzyloxy)-2,2-dimethyl-4-(phenylsulfonyl)but-3-enyl]-1,3-dithiane

Base Information

Chemical Name:2-[(E,1R)-1-(benzyloxy)-2,2-dimethyl-4-(phenylsulfonyl)but-3-enyl]-1,3-dithiane
CAS No.:277317-89-2
Molecular Formula:C₂₃H₂₈O₃S₃
Molecular Weight:448.672
Hs Code.:

Synonyms:2-[(E,1R)-1-(benzyloxy)-2,2-dimethyl-4-(phenylsulfonyl)but-3-enyl]-1,3-dithiane

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Chemical Property of 2-[(E,1R)-1-(benzyloxy)-2,2-dimethyl-4-(phenylsulfonyl)but-3-enyl]-1,3-dithiane

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Technology Process of 2-[(E,1R)-1-(benzyloxy)-2,2-dimethyl-4-(phenylsulfonyl)but-3-enyl]-1,3-dithiane

There total 6 articles about 2-[(E,1R)-1-(benzyloxy)-2,2-dimethyl-4-(phenylsulfonyl)but-3-enyl]-1,3-dithiane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 3112-85-4
methylphenylsulfonate

: 158499-74-2
(R)-(+)-3-(Benzyloxy)-3-(1,3-dithian-2-yl)-2,2-dimethylpropionaldehyd

: 277317-89-2
2-[(E,1R)-1-(benzyloxy)-2,2-dimethyl-4-(phenylsulfonyl)but-3-enyl]-1,3-dithiane

Guidance literature:: methylphenylsulfonate; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

With diethyl chlorophosphate; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

(R)-(+)-3-(Benzyloxy)-3-(1,3-dithian-2-yl)-2,2-dimethylpropionaldehyd; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 12h; Further stages.;
DOI:10.1039/a909549g

Reference yield:

: 3112-85-4
methylphenylsulfonate

: 277317-89-2
2-[(E,1R)-1-(benzyloxy)-2,2-dimethyl-4-(phenylsulfonyl)but-3-enyl]-1,3-dithiane

Guidance literature:: Multi-step reaction with 2 steps

1: n-BuLi / tetrahydrofuran / 0 °C

2: tetrahydrofuran / -78 - 20 °C

With n-butyllithium; In tetrahydrofuran; 1: Acylation / 2: Condensation;
DOI:10.1016/S0040-4039(99)00910-7