(S)-N-[(1R,2R)-2-(4-methylphenylsulfonamido)-1,2-diphenylethyl]pyrrolidine-2-carboxamide

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Chemical Name:(S)-N-[(1R,2R)-2-(4-methylphenylsulfonamido)-1,2-diphenylethyl]pyrrolidine-2-carboxamide
CAS No.:891790-61-7
Molecular Formula:C₂₆H₂₉N₃O₃S
Molecular Weight:463.601
Hs Code.:

Synonyms:(S)-N-[(1R,2R)-2-(4-methylphenylsulfonamido)-1,2-diphenylethyl]pyrrolidine-2-carboxamide

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Chemical Property of (S)-N-[(1R,2R)-2-(4-methylphenylsulfonamido)-1,2-diphenylethyl]pyrrolidine-2-carboxamide

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Technology Process of (S)-N-[(1R,2R)-2-(4-methylphenylsulfonamido)-1,2-diphenylethyl]pyrrolidine-2-carboxamide

There total 3 articles about (S)-N-[(1R,2R)-2-(4-methylphenylsulfonamido)-1,2-diphenylethyl]pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1360548-80-6
tert-butyl (S)-2-{[(1R,2R)-2-(4-methylphenylsulfonamido)-1,2-diphenylethyl]carbamoyl}pyrrolidine-1-carboxylate

: 891790-61-7
(S)-N-[(1R,2R)-2-(4-methylphenylsulfonamido)-1,2-diphenylethyl]pyrrolidine-2-carboxamide

Guidance literature:: With chlorotriisopropylsilane; Me₂S*CH₂Cl₂; trifluoroacetic acid; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201101164

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 891790-61-7
(S)-N-[(1R,2R)-2-(4-methylphenylsulfonamido)-1,2-diphenylethyl]pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2: tetrahydrofuran / 20 °C / Inert atmosphere

3: Me₂S*CH₂Cl₂; chlorotriisopropylsilane; trifluoroacetic acid / 0 - 20 °C / Inert atmosphere

With chlorotriisopropylsilane; Me₂S*CH₂Cl₂; triethylamine; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1002/ejoc.201101164

Reference yield:

: (S)-N-(tert-Butoxycarbonyl)proline ethyl carbonate

: 891790-61-7
(S)-N-[(1R,2R)-2-(4-methylphenylsulfonamido)-1,2-diphenylethyl]pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 °C / Inert atmosphere

2: Me₂S*CH₂Cl₂; chlorotriisopropylsilane; trifluoroacetic acid / 0 - 20 °C / Inert atmosphere

With chlorotriisopropylsilane; Me₂S*CH₂Cl₂; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1002/ejoc.201101164