(2R,3S)-methyl 2-(N-(9-phenylfluoren-9-yl)-N-methylamino)-3-hydroxypentanoate

Base Information

Chemical Name:(2R,3S)-methyl 2-(N-(9-phenylfluoren-9-yl)-N-methylamino)-3-hydroxypentanoate
CAS No.:126459-47-0
Molecular Formula:C₂₆H₂₇NO₃
Molecular Weight:401.505
Hs Code.:

Synonyms:(2R,3S)-methyl 2-(N-(9-phenylfluoren-9-yl)-N-methylamino)-3-hydroxypentanoate

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Chemical Property of (2R,3S)-methyl 2-(N-(9-phenylfluoren-9-yl)-N-methylamino)-3-hydroxypentanoate

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Technology Process of (2R,3S)-methyl 2-(N-(9-phenylfluoren-9-yl)-N-methylamino)-3-hydroxypentanoate

There total 6 articles about (2R,3S)-methyl 2-(N-(9-phenylfluoren-9-yl)-N-methylamino)-3-hydroxypentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 126459-46-9
(4R,5S)-methyl 3-(9-phenylfluoren-9-yl)-5-ethyloxazolidine-4-carboxylate

: 126459-47-0
(2R,3S)-methyl 2-(N-(9-phenylfluoren-9-yl)-N-methylamino)-3-hydroxypentanoate

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; In tetrahydrofuran; for 0.333333h;
DOI:10.1021/jo00298a025

Reference yield:

: 126459-44-7
(4S,5S)-3-(9-phenylfluoren-9-yl)-4-(hydroxymethyl)-5-ethyloxazolidine

: 126459-47-0
(2R,3S)-methyl 2-(N-(9-phenylfluoren-9-yl)-N-methylamino)-3-hydroxypentanoate

Guidance literature:: Multi-step reaction with 3 steps

2: 1) NaClO₂, NaH₂PO₄ / 1) H₂O, MeCN, tBuOH, r.t., 15 min

3: 90 percent / NaCNBH₃, 0.2 M HCl / tetrahydrofuran / 0.33 h

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; sodium cyanoborohydride; In tetrahydrofuran;
DOI:10.1021/jo00298a025

Reference yield:

: 126459-31-2
(4S)-3-(9-phenylfluoren-9-yl)-4-(1'-oxopropyl)oxazolidine

: 126459-47-0
(2R,3S)-methyl 2-(N-(9-phenylfluoren-9-yl)-N-methylamino)-3-hydroxypentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / LiAlH₄ / tetrahydrofuran / 0.25 h / -78 °C

3: 1) NaClO₂, NaH₂PO₄ / 1) H₂O, MeCN, tBuOH, r.t., 15 min

4: 90 percent / NaCNBH₃, 0.2 M HCl / tetrahydrofuran / 0.33 h

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; lithium aluminium tetrahydride; sodium cyanoborohydride; In tetrahydrofuran;
DOI:10.1021/jo00298a025