Ser-Asp

Base Information

• Chemical Name: Ser-Asp
• CAS No.: 2543-31-9
• Molecular Formula: C₇H₁₂N₂O₆
• Molecular Weight: 220.182
• Hs Code.: 2924199090
• Nikkaji Number: J332.022G
• Wikidata: Q27144918
• Metabolomics Workbench ID: 78959
• ChEMBL ID: CHEMBL302607
• Mol file: 2543-31-9.mol

Synonyms:H-SER-ASP-OH;Ser-Asp;2543-31-9;L-seryl-L-aspartic acid;serylaspartic acid;CHEBI:74807;(S)-2-((S)-2-Amino-3-hydroxyPropanamido)succinic acid;Serinylaspartate;SD dipeptide;Serinyl-Aspartate;S-D Dipeptide;Seryl-aspartic acid;L-Ser-L-Asp;L-Serinyl-L-Aspartate;Serine Aspartate dipeptide;Serine-Aspartate dipeptide;CHEMBL302607;HY-P4501;SD;MFCD00057828;CS-0654492;Q27144918;(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]butanedioic acid

Chemical Property of Ser-Asp

Chemical Property:

• Melting Point: 177 °C
• Boiling Point: 581.3±50.0 °C(Predicted)
• PKA: 2.82±0.10(Predicted)
• PSA: 153.44000
• Density: 1.559±0.06 g/cm3(Predicted)
• LogP: -1.10930
• Storage Temp.: -15°C
• XLogP3: -5.2
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 220.06953611
• Heavy Atom Count: 15
• Complexity: 266

Purity/Quality:

98%Min ^*data from raw suppliers

H-Ser-Asp-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C(C(C(=O)O)NC(=O)C(CO)N)C(=O)O
• Isomeric SMILES: C([C@@H](C(=O)O)NC(=O)[C@H](CO)N)C(=O)O
• Recent ClinicalTrials: Study of GSK961081 in Healthy Volunteer Subjects
• Uses: H-Ser-Asp-OH is used in the preparation polypeptide compounds for enhancement of immune system.

Technology Process of Ser-Asp

There total 4 articles about Ser-Asp which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-((S)-2-Amino-3-benzyloxy-propionylamino)-succinic acid dibenzyl ester; compound with trifluoro-acetic acid (129276-58-0) → N-L-seryl-L-aspartic acid (2543-31-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; water; for 22h; under 760 Torr; Ambient temperature;

DOI:10.1021/jm00170a012

Reference yield:

BocS(OBzl)D(OBzl)OBzl (127103-15-5) → N-L-seryl-L-aspartic acid (2543-31-9)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 2 h / Ambient temperature

2: H₂ / 10percent Pd/C / methanol; H₂O / 22 h / 760 Torr / Ambient temperature

With hydrogen; palladium on activated charcoal; In methanol; dichloromethane; water;

DOI:10.1021/jm00170a012

Reference yield:

N-(N-benzyloxycarbonyl-L-seryl)-L-aspartic acid dibenzyl ester (3695-65-6) → N-L-seryl-L-aspartic acid (2543-31-9)

Guidance literature:

With palladium on activated charcoal; ethanol; Hydrogenation;

upstream raw materials:

N-(N-benzyloxycarbonyl-L-seryl)-L-aspartic acid dibenzyl ester

(S)-2-((S)-2-Amino-3-benzyloxy-propionylamino)-succinic acid dibenzyl ester; compound with trifluoro-acetic acid

BocS(OBzl)D(OBzl)OBzl

Refernces