6-(ethylsulfonyl)-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

Base Information

Chemical Name:6-(ethylsulfonyl)-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine
CAS No.:1383377-02-3
Molecular Formula:C₁₉H₁₉FN₄O₂S
Molecular Weight:386.45
Hs Code.:

Synonyms:6-(ethylsulfonyl)-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

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Chemical Property of 6-(ethylsulfonyl)-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

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Technology Process of 6-(ethylsulfonyl)-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

There total 2 articles about 6-(ethylsulfonyl)-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1383377-79-4
4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)isoindoline

: 594-44-5
Ethanesulfonyl chloride

: 1383377-02-3
6-(ethylsulfonyl)-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

Guidance literature:: With triethylamine; In dichloromethane; for 0.0833333h;

Reference yield:

: 1383377-78-3
ethyl 4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

: 1383377-02-3
6-(ethylsulfonyl)-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide; water / methanol / 18 h / 90 °C

2: triethylamine / dichloromethane / 0.08 h

With water; triethylamine; potassium hydroxide; In methanol; dichloromethane;

Reference yield: 100.0%

: 1383377-02-3
6-(ethylsulfonyl)-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

: 802294-64-0,79-09-4
propionic acid

: 4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6-propionyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine hydrochloride

Guidance literature:: 6-(ethylsulfonyl)-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine; propionic acid; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethyl acetate; at 20 ℃; for 2h;

With hydrogenchloride; In diethyl ether; ethyl acetate;