[N-(4-toluoylsulfonyl)-N-allyl]-(S)-valinyl-(S)-prolinyl-(S)-leucinyl-allylglycine methyl ester

Base Information

Chemical Name:[N-(4-toluoylsulfonyl)-N-allyl]-(S)-valinyl-(S)-prolinyl-(S)-leucinyl-allylglycine methyl ester
CAS No.:253608-35-4
Molecular Formula:C₃₂H₄₈N₄O₇S
Molecular Weight:632.822
Hs Code.:

Synonyms:[N-(4-toluoylsulfonyl)-N-allyl]-(S)-valinyl-(S)-prolinyl-(S)-leucinyl-allylglycine methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [N-(4-toluoylsulfonyl)-N-allyl]-(S)-valinyl-(S)-prolinyl-(S)-leucinyl-allylglycine methyl ester

Chemical Property:

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Technology Process of [N-(4-toluoylsulfonyl)-N-allyl]-(S)-valinyl-(S)-prolinyl-(S)-leucinyl-allylglycine methyl ester

There total 3 articles about [N-(4-toluoylsulfonyl)-N-allyl]-(S)-valinyl-(S)-prolinyl-(S)-leucinyl-allylglycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 233591-88-3
N-(4-toluoylsulfonyl)-(S)-valinyl-(S)-prolinyl-(S)-leucinyl-allylglycine methyl ester

: 12012-95-2
?-allylpalladium chloride dimer

: 253608-35-4
[N-(4-toluoylsulfonyl)-N-allyl]-(S)-valinyl-(S)-prolinyl-(S)-leucinyl-allylglycine methyl ester

Guidance literature:: With diallylcarbonate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1021/ol9910262

Reference yield: 75.0%

: 233591-88-3
N-(4-toluoylsulfonyl)-(S)-valinyl-(S)-prolinyl-(S)-leucinyl-allylglycine methyl ester

: 1469-70-1
allyl ethyl carbonate

: 253608-35-4
[N-(4-toluoylsulfonyl)-N-allyl]-(S)-valinyl-(S)-prolinyl-(S)-leucinyl-allylglycine methyl ester

Guidance literature:: With bis(η3-allyl-μ-chloropalladium(II)); triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1039/b411228h

Reference yield:

: 2-[(S)-4-Methyl-2-({(S)-1-[(S)-3-methyl-2-(toluene-4-sulfonylamino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-pentanoylamino]-pent-4-enoic acid

: 253608-35-4
[N-(4-toluoylsulfonyl)-N-allyl]-(S)-valinyl-(S)-prolinyl-(S)-leucinyl-allylglycine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 0.17 h

2: 75 percent / triphenylphosphine; allyl carbonate / tetrahydrofuran / 16 h / 20 °C

With diallylcarbonate; triphenylphosphine; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ol9910262