tert-Butyl-diphenyl-[(1R,3R)-2,2,3-trimethyl-3-((R)-1-methyl-but-3-ynyl)-cyclopentylmethoxy]-silane

Base Information

Chemical Name:tert-Butyl-diphenyl-[(1R,3R)-2,2,3-trimethyl-3-((R)-1-methyl-but-3-ynyl)-cyclopentylmethoxy]-silane
CAS No.:463314-50-3
Molecular Formula:C₃₀H₄₂OSi
Molecular Weight:446.748
Hs Code.:

Synonyms:tert-Butyl-diphenyl-[(1R,3R)-2,2,3-trimethyl-3-((R)-1-methyl-but-3-ynyl)-cyclopentylmethoxy]-silane

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Chemical Property of tert-Butyl-diphenyl-[(1R,3R)-2,2,3-trimethyl-3-((R)-1-methyl-but-3-ynyl)-cyclopentylmethoxy]-silane

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Technology Process of tert-Butyl-diphenyl-[(1R,3R)-2,2,3-trimethyl-3-((R)-1-methyl-but-3-ynyl)-cyclopentylmethoxy]-silane

There total 8 articles about tert-Butyl-diphenyl-[(1R,3R)-2,2,3-trimethyl-3-((R)-1-methyl-but-3-ynyl)-cyclopentylmethoxy]-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 27491-70-9,28447-24-7,25411-73-8
dimethyl diazomethylphosphonate

: 463314-47-8
(R)-3-[(1R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-1,2,2-trimethyl-cyclopentyl]-butyraldehyde

: 463314-50-3
tert-Butyl-diphenyl-[(1R,3R)-2,2,3-trimethyl-3-((R)-1-methyl-but-3-ynyl)-cyclopentylmethoxy]-silane

Guidance literature:: dimethyl diazomethylphosphonate; With potassium tert-butylate; In tetrahydrofuran; at -78 ℃; for 1h;

(R)-3-[(1R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-1,2,2-trimethyl-cyclopentyl]-butyraldehyde; In tetrahydrofuran; at -75 - 20 ℃; for 16h;
DOI:10.1016/S0960-894X(02)00222-6

Reference yield:

: 463314-43-4
(S)-2-[(1R,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-1,2,2-trimethyl-cyclopentyl]-propionaldehyde

: 463314-50-3
tert-Butyl-diphenyl-[(1R,3R)-2,2,3-trimethyl-3-((R)-1-methyl-but-3-ynyl)-cyclopentylmethoxy]-silane

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA; HMPA / tetrahydrofuran / 1 h / -20 - 0 °C

1.2: tetrahydrofuran / 2.5 h / -40 - 20 °C

2.1: Hg(OAc)2 / tetrahydrofuran / 1 h / 20 °C

2.2: 7 percent KI

3.1: t-BuOK / tetrahydrofuran / 1 h / -78 °C

3.2: 93 percent / tetrahydrofuran / 16 h / -75 - 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium tert-butylate; mercury(II) diacetate; lithium diisopropyl amide; In tetrahydrofuran; 3.2: Seyferth's reaction;
DOI:10.1016/S0960-894X(02)00222-6

Reference yield:

: 463314-42-3
2-[3-(tert-butyl-diphenyl-silanyloxymethyl)-1,2,2-trimethyl-cyclopentyl]-propionaldehyde

: 463314-50-3
tert-Butyl-diphenyl-[(1R,3R)-2,2,3-trimethyl-3-((R)-1-methyl-but-3-ynyl)-cyclopentylmethoxy]-silane

Guidance literature:: Multi-step reaction with 4 steps

1.1: 45 percent / DBU / CH₂Cl₂ / 12 h / 20 °C

2.1: LDA; HMPA / tetrahydrofuran / 1 h / -20 - 0 °C

2.2: tetrahydrofuran / 2.5 h / -40 - 20 °C

3.1: Hg(OAc)2 / tetrahydrofuran / 1 h / 20 °C

3.2: 7 percent KI

4.1: t-BuOK / tetrahydrofuran / 1 h / -78 °C

4.2: 93 percent / tetrahydrofuran / 16 h / -75 - 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium tert-butylate; mercury(II) diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 4.2: Seyferth's reaction;
DOI:10.1016/S0960-894X(02)00222-6