N-(3-fluoro-4-(5-phenylthieno[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Chemical Name:N-(3-fluoro-4-(5-phenylthieno[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
CAS No.:1321618-80-7
Molecular Formula:C₃₀H₁₈F₂N₄O₃S
Molecular Weight:552.561
Hs Code.:

Synonyms:N-(3-fluoro-4-(5-phenylthieno[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Chemical Property of N-(3-fluoro-4-(5-phenylthieno[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Technology Process of N-(3-fluoro-4-(5-phenylthieno[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

There total 2 articles about N-(3-fluoro-4-(5-phenylthieno[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.1%

: 868171-67-9
1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

: 1321618-70-5
3-fluoro-4-({5-phenylthieno[2,3-d]pyrimidin-4-yl}oxy)aniline

: 1321618-80-7
N-(3-fluoro-4-(5-phenylthieno[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2011.05.038

Reference yield:

: 399-96-2
4-amino-2-fluorophenol

: 182198-35-2
4-chloro-5-phenyl-thieno[2,3-d]pyrimidine

: 1321618-80-7
N-(3-fluoro-4-(5-phenylthieno[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 °C / Inert atmosphere

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.038