4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanol

Base Information

Chemical Name:4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanol
CAS No.:1361144-94-6
Molecular Formula:C₂₅H₄₆N₄O₄Si₂
Molecular Weight:522.836
Hs Code.:

Synonyms:4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanol

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Chemical Property of 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanol

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Technology Process of 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanol

There total 5 articles about 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361144-93-5
5-(4-methylenecyclohexyl)-N,N-bis((2-(trimethylsilyl)ethoxy)methyl)pyrazolo[1,5-a]pyrimidin-7-amine

: 1361144-94-6
4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanol

Guidance literature:: With water; 4-methylmorpholine N-oxide; osmium(VIII) oxide; In acetone; acetonitrile; tert-butyl alcohol; at 20 ℃;

Reference yield:

: 145576-28-9
ethyl 4-methylidenecyclohexanecarboxylate

: 1361144-94-6
4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / -78 °C

2.1: acetic acid / 100 °C / sealed tube

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 45 °C

4.1: water; 4-methylmorpholine N-oxide / osmium(VIII) oxide / acetonitrile; tert-butyl alcohol; acetone / 20 °C

With n-butyllithium; water; acetic acid; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; osmium(VIII) oxide; In tetrahydrofuran; dichloromethane; acetone; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1361144-92-4
3-(4-methylenecyclohexyl)-3-oxopropanenitrile

: 1361144-94-6
4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 100 °C / sealed tube

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 45 °C

3: water; 4-methylmorpholine N-oxide / osmium(VIII) oxide / acetonitrile; tert-butyl alcohol; acetone / 20 °C

With water; acetic acid; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; osmium(VIII) oxide; In dichloromethane; acetone; acetonitrile; tert-butyl alcohol;