BOC-THR-OH DCHA

Base Information

• Chemical Name: BOC-THR-OH DCHA
• CAS No.: 23082-30-6
• Molecular Formula: C₉H₁₇NO₅
• Molecular Weight: 219.238
• Mol file: 23082-30-6.mol

Synonyms:Allothreonine,N-carboxy-, N-tert-butyl ester, L- (8CI); BOC-L-allothreonine;N-tert-Butoxycarbonyl-L-allothreonine; N-tert-Butyloxycarbonyl-L-allothreonine

Chemical Property of BOC-THR-OH DCHA

Chemical Property:

• Melting Point: 115 °C
• Boiling Point: 387.1±37.0 °C(Predicted)
• PKA: 3.60±0.10(Predicted)
• PSA: 107.89000
• Density: 1.202±0.06 g/cm3(Predicted)
• LogP: 4.36830
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Boc-L-allo-Thr-OH*DCHA ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-THR-OH DCHA

There total 21 articles about BOC-THR-OH DCHA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2S,3S)-2-amino-3-hydroxybutanoic acid (28954-12-3,134357-96-3,7013-32-3,82822-12-6) + di-tert-butyl dicarbonate (24424-99-5) → N-tert-butoxycarbonyl-L-allo-threonine (2592-18-9,23082-29-3,55674-67-4,85979-33-5,86748-77-8,23082-30-6)

Guidance literature:

In methanol; water; at 20 ℃; for 24h;

DOI:10.1039/C8OB01756E

Reference yield: 100.0%

D-Threonine (632-20-2,134357-96-3,7013-32-3,82822-12-6) + di-tert-butyl dicarbonate (24424-99-5) → (2R,3S)-2-tert-butoxycarbonylamino-3-hydroxybutyric acid (2592-18-9,23082-29-3,23082-30-6,55674-67-4,85979-33-5,86748-77-8)

Guidance literature:

With sodium hydroxide; In water; tert-butyl alcohol; at 20 ℃; for 23h;

DOI:10.1016/j.febslet.2013.07.016

Reference yield: 99.4%

di-tert-butyl dicarbonate (24424-99-5) + (2R,3S)-2-amino-3-hydroxybutanoic acid hydrochloride → (2R,3S)-2-tert-butoxycarbonylamino-3-hydroxybutyric acid (2592-18-9,23082-29-3,23082-30-6,55674-67-4,85979-33-5,86748-77-8)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; Cooling with ice;

upstream raw materials:

D-allo-threonine

di-tert-butyl dicarbonate

(2S,3S)-2-amino-3-hydroxybutanoic acid

N-(tert-butyloxycarbonyl) azide

Downstream raw materials:

BOC-D-α-Thr-OBn

C₁₉H₂₈N₂O₆

Boc-aThr-(N^ε-Z-Lys-OCH3)

((1S,2S)-2-Hydroxy-1-methoxycarbamoyl-propyl)-carbamic acid tert-butyl ester

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