(4aR,8aR)-(+)-4a,5,6,7,8,8a-hexahydro-1,1,3,6,6-pentamethyl-4-(p-toluenesulfenyl)-1H-2-benzopyran

Base Information

• Chemical Name: (4aR,8aR)-(+)-4a,5,6,7,8,8a-hexahydro-1,1,3,6,6-pentamethyl-4-(p-toluenesulfenyl)-1H-2-benzopyran
• CAS No.: 145627-36-7
• Molecular Formula: C₂₁H₃₀OS
• Molecular Weight: 330.535
• Mol file: 145627-36-7.mol

Synonyms:(4aR,8aR)-(+)-4a,5,6,7,8,8a-hexahydro-1,1,3,6,6-pentamethyl-4-(p-toluenesulfenyl)-1H-2-benzopyran

Chemical Property of (4aR,8aR)-(+)-4a,5,6,7,8,8a-hexahydro-1,1,3,6,6-pentamethyl-4-(p-toluenesulfenyl)-1H-2-benzopyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4aR,8aR)-(+)-4a,5,6,7,8,8a-hexahydro-1,1,3,6,6-pentamethyl-4-(p-toluenesulfenyl)-1H-2-benzopyran

There total 10 articles about (4aR,8aR)-(+)-4a,5,6,7,8,8a-hexahydro-1,1,3,6,6-pentamethyl-4-(p-toluenesulfenyl)-1H-2-benzopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(4aR,8aR,SS)-4a,5,6,7,8,8a-hexahydro-1,1,3,6,6-pentamethyl-4-(p-toluenesulfinyl)-1H-2-benzopyran (145627-37-8) → (4aR,8aR)-(+)-4a,5,6,7,8,8a-hexahydro-1,1,3,6,6-pentamethyl-4-(p-toluenesulfenyl)-1H-2-benzopyran (145627-36-7)

Guidance literature:

With titanium(III) chloride; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1248/cpb.45.759

Reference yield: 7.0%

(1R,2R,αR,Rs)-(+)-1-(5,5-dimethyl-2-isopropylencyclohexyl)-1-p-toluenesulfinyl-2-propanone (145627-33-4) → (4aR,8aR)-(+)-4a,5,6,7,8,8a-hexahydro-1,1,3,6,6-pentamethyl-4-(p-toluenesulfenyl)-1H-2-benzopyran (145627-36-7)

Guidance literature:

With titanium(III) chloride; In tetrahydrofuran; for 8h; Ambient temperature;

DOI:10.1248/cpb.41.666

Reference yield:

(1R,2R,αS,Rs)-(-)-1-(5,5-dimethyl-2-isopropenylcyclohexyl)-1-p-toluenesulfinyl-2-propanone (145679-83-0) → (4aR,8aR)-(+)-4a,5,6,7,8,8a-hexahydro-1,1,3,6,6-pentamethyl-4-(p-toluenesulfenyl)-1H-2-benzopyran (145627-36-7)

Guidance literature:

With titanium(III) chloride; In tetrahydrofuran; for 8h; Ambient temperature;

DOI:10.1248/cpb.41.666

upstream raw materials:

(1R,2R,αR,Rs)-(+)-1-(5,5-dimethyl-2-isopropylencyclohexyl)-1-p-toluenesulfinyl-2-propanone

(1R,2R,αS,Rs)-(-)-1-(5,5-dimethyl-2-isopropenylcyclohexyl)-1-p-toluenesulfinyl-2-propanone

(4aR,8aR,S_S)-4a,5,6,7,8,8a-hexahydro-1,1,3,6,6-pentamethyl-4-(p-toluenesulfinyl)-1H-2-benzopyran

(S)-(+)-1-methyl 4-methylbenzenesulfinate