5-(4-(1-phenoxyethyl)-1H-1,2,3-triazol-1-yl)-2-(thiazol-5-yl)benzo[d]oxazole

Base Information

Chemical Name:5-(4-(1-phenoxyethyl)-1H-1,2,3-triazol-1-yl)-2-(thiazol-5-yl)benzo[d]oxazole
CAS No.:1434517-40-4
Molecular Formula:C₂₀H₁₅N₅O₂S
Molecular Weight:389.437
Hs Code.:

Synonyms:5-(4-(1-phenoxyethyl)-1H-1,2,3-triazol-1-yl)-2-(thiazol-5-yl)benzo[d]oxazole

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Chemical Property of 5-(4-(1-phenoxyethyl)-1H-1,2,3-triazol-1-yl)-2-(thiazol-5-yl)benzo[d]oxazole

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Technology Process of 5-(4-(1-phenoxyethyl)-1H-1,2,3-triazol-1-yl)-2-(thiazol-5-yl)benzo[d]oxazole

There total 5 articles about 5-(4-(1-phenoxyethyl)-1H-1,2,3-triazol-1-yl)-2-(thiazol-5-yl)benzo[d]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1596-40-3
phenyl α-methylpropargyl ether

: 1434519-02-4
5-azido-2-(thiazol-5-yl)benzo[d]oxazole

: 1434517-40-4
5-(4-(1-phenoxyethyl)-1H-1,2,3-triazol-1-yl)-2-(thiazol-5-yl)benzo[d]oxazole

Guidance literature:: phenyl α-methylpropargyl ether; 5-azido-2-(thiazol-5-yl)benzo[d]oxazole; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 0.166667h; Inert atmosphere;

With copper(l) iodide; In acetonitrile; for 0.666667h; Inert atmosphere;
DOI:10.1021/jm400241j

Reference yield:

: 108-95-2,27073-41-2
phenol

: 1434517-40-4
5-(4-(1-phenoxyethyl)-1H-1,2,3-triazol-1-yl)-2-(thiazol-5-yl)benzo[d]oxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: 20 h / 70 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.17 h / 20 °C / Inert atmosphere

2.2: 0.67 h / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm400241j

Reference yield:

: 1434518-52-1
2-(thiazol-5-yl)benzo[d]oxazol-5-amine

: 1434517-40-4
5-(4-(1-phenoxyethyl)-1H-1,2,3-triazol-1-yl)-2-(thiazol-5-yl)benzo[d]oxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 1 h / -5 °C / Inert atmosphere

1.2: 0.5 h / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.17 h / 20 °C / Inert atmosphere

2.2: 0.67 h / Inert atmosphere

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; sodium nitrite; In water; acetonitrile;
DOI:10.1021/jm400241j