2-{5-chloro-2-[5,5-dimethyl-2-oxo-3-(2,2,2-trifluoroacetylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-8-ylamino]pyrimidin-4-ylamino}-3-fluoro-N-methylbenzamide

Base Information

Chemical Name:2-{5-chloro-2-[5,5-dimethyl-2-oxo-3-(2,2,2-trifluoroacetylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-8-ylamino]pyrimidin-4-ylamino}-3-fluoro-N-methylbenzamide
CAS No.:1022945-74-9
Molecular Formula:C₂₆H₂₄ClF₄N₇O₃
Molecular Weight:593.968
Hs Code.:

2-{5-chloro-2-[5,5-dimethyl-2-oxo-3-(2,2,2-trifluoroacetylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-8-ylamino]pyrimidin-4-ylamino}-3-fluoro-N-methylbenzamide

Synonyms:2-{5-chloro-2-[5,5-dimethyl-2-oxo-3-(2,2,2-trifluoroacetylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-8-ylamino]pyrimidin-4-ylamino}-3-fluoro-N-methylbenzamide

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Chemical Property of 2-{5-chloro-2-[5,5-dimethyl-2-oxo-3-(2,2,2-trifluoroacetylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-8-ylamino]pyrimidin-4-ylamino}-3-fluoro-N-methylbenzamide

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Technology Process of 2-{5-chloro-2-[5,5-dimethyl-2-oxo-3-(2,2,2-trifluoroacetylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-8-ylamino]pyrimidin-4-ylamino}-3-fluoro-N-methylbenzamide

There total 6 articles about 2-{5-chloro-2-[5,5-dimethyl-2-oxo-3-(2,2,2-trifluoroacetylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-8-ylamino]pyrimidin-4-ylamino}-3-fluoro-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 959246-74-3
2-(2,5-dichloro-pyrimidin-4-ylamino)-3-fluoro-N-methyl-benzamide

: 1022972-73-1
N-(8-amino-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl)-2,2,2-trifluoroacetamide

: 1022945-74-9
2-{5-chloro-2-[5,5-dimethyl-2-oxo-3-(2,2,2-trifluoroacetylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-8-ylamino]pyrimidin-4-ylamino}-3-fluoro-N-methylbenzamide

Guidance literature:: With camphor-10-sulfonic acid; In isopropyl alcohol; at 120 ℃; for 0.5h; Microwave irradiation;
DOI:10.1016/j.bmc.2011.09.006

Reference yield:

: 1022972-67-3
3-azido-5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-1-benzazepin-2-one

: 1022945-74-9
2-{5-chloro-2-[5,5-dimethyl-2-oxo-3-(2,2,2-trifluoroacetylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-8-ylamino]pyrimidin-4-ylamino}-3-fluoro-N-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: polystyrene-triphenylphosphine resin / tetrahydrofuran; water / 20 °C

2: pyridine / dichloromethane / 1 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 1.5 h / 2068.65 Torr

4: camphor-10-sulfonic acid / isopropyl alcohol / 0.5 h / 120 °C / Microwave irradiation

With pyridine; palladium 10% on activated carbon; camphor-10-sulfonic acid; hydrogen; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol; 1: Staudinger reaction;
DOI:10.1016/j.bmc.2011.09.006

Reference yield:

: 1022972-64-0
5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-benzo[b]azepin-2-one

: 1022945-74-9
2-{5-chloro-2-[5,5-dimethyl-2-oxo-3-(2,2,2-trifluoroacetylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-8-ylamino]pyrimidin-4-ylamino}-3-fluoro-N-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine / dichloromethane / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: sodium azide / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: polystyrene-triphenylphosphine resin / tetrahydrofuran; water / 20 °C

4.1: pyridine / dichloromethane / 1 h / 20 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol / 1.5 h / 2068.65 Torr

6.1: camphor-10-sulfonic acid / isopropyl alcohol / 0.5 h / 120 °C / Microwave irradiation

With pyridine; sodium azide; trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; palladium 10% on activated carbon; camphor-10-sulfonic acid; hydrogen; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 3.1: Staudinger reaction;
DOI:10.1016/j.bmc.2011.09.006