4-(3-TRIFLUOROMETHYL-PHENOXY)-PIPERIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 4-(3-TRIFLUOROMETHYL-PHENOXY)-PIPERIDINE HYDROCHLORIDE
• CAS No.: 28033-33-2
• Molecular Formula: C12H14 F3 N O . Cl H
• Molecular Weight: 281.705
• Hs Code.: 2933399090
• Mol file: 28033-33-2.mol

Synonyms:Piperidine,4-[(a,a,a-trifluoro-m-tolyl)oxy]-, hydrochloride (8CI); Piperidine, 4-[3-(trifluoromethyl)phenoxy]-,hydrochloride (9CI)

Chemical Property of 4-(3-TRIFLUOROMETHYL-PHENOXY)-PIPERIDINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.000171mmHg at 25°C
• Boiling Point: 325.1°C at 760 mmHg
• Flash Point: 150.4°C
• PSA: 21.26000
• LogP: 3.96700

Purity/Quality:

98%min ^*data from raw suppliers

4-[3-(Trifluoromethyl)phenoxy]piperidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-TRIFLUOROMETHYL-PHENOXY)-PIPERIDINE HYDROCHLORIDE

There total 1 articles about 4-(3-TRIFLUOROMETHYL-PHENOXY)-PIPERIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(3-(trifluoromethyl)phenoxy)piperidine-1-carboxylate → 4-(3-(trifluoromethyl)phenoxy)piperidine hydrochloride (28033-33-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 25 ℃; for 2h;

Reference yield: 34.0%

[(5-phenyl-isoxazole-3-carbonyl)-amino]-acetic acid (176593-99-0) + 4-(3-(trifluoromethyl)phenoxy)piperidine hydrochloride (28033-33-2) → 5-phenylisoxazole-3-carboxylic acid {2-oxo-2-[4-(3-trifluoromethylphenoxy)piperidin-1-yl]-ethyl}amide (1188373-19-4)

Guidance literature:

[(5-phenyl-isoxazole-3-carbonyl)-amino]-acetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.0333333h;

4-(3-(trifluoromethyl)phenoxy)piperidine hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 30.0%

bis(trichloromethyl) carbonate (32315-10-9) + 4-(3-(trifluoromethyl)phenoxy)piperidine hydrochloride (28033-33-2) + 3-amino-1-methyl-1,6-dihydropyridazin-6-one (13506-28-0) → N-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-4-(3-(trifluoromethyl)phenoxy)piperidine-1-carboxamide

Guidance literature:

bis(trichloromethyl) carbonate; 3-amino-1-methyl-1,6-dihydropyridazin-6-one; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at 0 ℃; for 1h;

4-(3-(trifluoromethyl)phenoxy)piperidine hydrochloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at 25 ℃; for 16h;

Downstream raw materials:

5-phenylisoxazole-3-carboxylic acid {2-oxo-2-[4-(3-trifluoromethylphenoxy)piperidin-1-yl]-ethyl}amide

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