(S)-2-(4-methylphenylsulfonamido)-4-(neopentylamino)-4-oxobutanoic acid

Base Information

Chemical Name:(S)-2-(4-methylphenylsulfonamido)-4-(neopentylamino)-4-oxobutanoic acid
CAS No.:890660-09-0
Molecular Formula:C₁₆H₂₄N₂O₅S
Molecular Weight:356.443
Hs Code.:

Synonyms:(S)-2-(4-methylphenylsulfonamido)-4-(neopentylamino)-4-oxobutanoic acid

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Chemical Property of (S)-2-(4-methylphenylsulfonamido)-4-(neopentylamino)-4-oxobutanoic acid

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Technology Process of (S)-2-(4-methylphenylsulfonamido)-4-(neopentylamino)-4-oxobutanoic acid

There total 4 articles about (S)-2-(4-methylphenylsulfonamido)-4-(neopentylamino)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: (S)-2-amino-4-(neopentylamino)-4-oxobutanoic acid hydrochloride

: 104-15-4
toluene-4-sulfonic acid

: 890660-09-0
(S)-2-(4-methylphenylsulfonamido)-4-(neopentylamino)-4-oxobutanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; for 2h; pH=> 8; Cooling with ice;
DOI:10.1016/j.ejmech.2020.112160

Reference yield: 60.0%

: (S)-2-amino-4-(neopentylamino)-4-oxobutanoic acid hydrochloride

: 98-59-9
p-toluenesulfonyl chloride

: 890660-09-0
(S)-2-(4-methylphenylsulfonamido)-4-(neopentylamino)-4-oxobutanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; for 2h;
DOI:10.1021/jm058289o

Reference yield:

: 890660-33-0
Boc-neopentyl-Asn-O-tBu

: 890660-09-0
(S)-2-(4-methylphenylsulfonamido)-4-(neopentylamino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / HCl / dioxane / 2 h

2: 60 percent / aq. NaOH / tetrahydrofuran / 2 h

With hydrogenchloride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; 2: Schotten-Bauman reaction;
DOI:10.1021/jm058289o