3-(3-(1H-indol-6-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-n,n-dimethylbenzenesulfonamide

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Chemical Name:3-(3-(1H-indol-6-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-n,n-dimethylbenzenesulfonamide
CAS No.:1186421-66-8
Molecular Formula:C₂₇H₂₂N₆O₂S
Molecular Weight:494.577
Hs Code.:

Synonyms:3-(3-(1H-indol-6-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-n,n-dimethylbenzenesulfonamide

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Chemical Property of 3-(3-(1H-indol-6-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-n,n-dimethylbenzenesulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(3-(1H-indol-6-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-n,n-dimethylbenzenesulfonamide

There total 5 articles about 3-(3-(1H-indol-6-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-n,n-dimethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1186422-01-4
3-(3-iodo-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-N,N-dimethylbenzenesulfonamide

: 147621-18-9
6-indolylboronic acid

: 1186421-66-8
3-(3-(1H-indol-6-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-n,n-dimethylbenzenesulfonamide

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; at 80 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1186421-98-6
N,N-dimethyl-3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)benzenesulfonamide

: 1186421-66-8
3-(3-(1H-indol-6-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-n,n-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-iodo-succinimide / chloroform / 4.5 h / 20 °C

2: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 4 h / 80 °C / Inert atmosphere

With N-iodo-succinimide; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; chloroform; 2: Suzuki Coupling;

Reference yield:

: 1310456-95-1
3-(3-(dimethylamino)acryloyl)-N,N-dimethylbenzenesulfonamide

: 1186421-66-8
3-(3-(1H-indol-6-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-n,n-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 3.5 h / 80 °C

2: N-iodo-succinimide / chloroform / 4.5 h / 20 °C

3: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 4 h / 80 °C / Inert atmosphere

With N-iodo-succinimide; potassium carbonate; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; chloroform; 3: Suzuki Coupling;