1-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]-1-oxoacetone

Base Information

Chemical Name:1-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]-1-oxoacetone
CAS No.:853020-60-7
Molecular Formula:C₂₆H₂₉N₃O₄
Molecular Weight:447.534
Hs Code.:

Synonyms:1-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]-1-oxoacetone

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Chemical Property of 1-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]-1-oxoacetone

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Technology Process of 1-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]-1-oxoacetone

There total 8 articles about 1-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]-1-oxoacetone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-methoxy-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine]

: 127-17-3
2-oxo-propionic acid

: 853020-60-7
1-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]-1-oxoacetone

Guidance literature:: With pyridine; trichlorophosphate; In tetrahydrofuran; at -15 - 20 ℃; for 0.75h;

Reference yield:

: 66-83-1
5-methoxytryptamine hydrochloride

: 853020-60-7
1-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]-1-oxoacetone

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 1 h / 100 °C

1.2: 72 h

2.1: chiral preparative HPLC_.; Resolution of racemate

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 - 60 °C

4.1: pyridine; trichlorophosphate / tetrahydrofuran / 0.75 h / -15 - 20 °C

With pyridine; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

: 853020-88-9,853020-89-0,853020-91-4
1'-benzyl-6-methoxy-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine]

: 853020-60-7
1-[6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidin]-2(3H)-yl]-1-oxoacetone

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium dihydroxide / methanol; water / 58 °C

2: chiral preparative HPLC_.; Resolution of racemate

3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 - 60 °C

4: pyridine; trichlorophosphate / tetrahydrofuran / 0.75 h / -15 - 20 °C

With pyridine; hydrogen; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium dihydroxide; In tetrahydrofuran; methanol; water; dimethyl sulfoxide;