3-(3-oxo-4,4a,5,6-tetrahydrobenzo[h]cinnolin-2(3H)-yl)propyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate

Base Information

Chemical Name:3-(3-oxo-4,4a,5,6-tetrahydrobenzo[h]cinnolin-2(3H)-yl)propyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate
CAS No.:1459195-55-1
Molecular Formula:C₂₉H₃₅N₃O₅
Molecular Weight:505.614
Hs Code.:

Synonyms:3-(3-oxo-4,4a,5,6-tetrahydrobenzo[h]cinnolin-2(3H)-yl)propyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate

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Chemical Property of 3-(3-oxo-4,4a,5,6-tetrahydrobenzo[h]cinnolin-2(3H)-yl)propyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate

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Technology Process of 3-(3-oxo-4,4a,5,6-tetrahydrobenzo[h]cinnolin-2(3H)-yl)propyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate

There total 2 articles about 3-(3-oxo-4,4a,5,6-tetrahydrobenzo[h]cinnolin-2(3H)-yl)propyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 4530-18-1
2-(tert-butoxycarbonylamino)-3-phenylpropionic acid

: 1459195-53-9
2-(3-hydroxypropyl)-4,4a,5,6-tetrahydrobenzo[h]cinnolin-3(2H)-one

: 1459195-55-1
3-(3-oxo-4,4a,5,6-tetrahydrobenzo[h]cinnolin-2(3H)-yl)propyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate

Guidance literature:: With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 24h; pH=7;
DOI:10.1039/c3md00095h

Reference yield:

: 25823-48-7,121866-05-5
4,4a,5,6-tetrahydrobenzocinnolin-3(2H)-one

: 1459195-55-1
3-(3-oxo-4,4a,5,6-tetrahydrobenzo[h]cinnolin-2(3H)-yl)propyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

1.2: 4 h / 60 °C / Inert atmosphere

2.1: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 24 h / 20 °C / pH 7

With 4-methyl-morpholine; sodium hydride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3md00095h

Reference yield: 50.0%

: 1459195-55-1
3-(3-oxo-4,4a,5,6-tetrahydrobenzo[h]cinnolin-2(3H)-yl)propyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate

: 1459195-94-8
C₂₄H₂₇N₃O₃

Guidance literature:: 3-(3-oxo-4,4a,5,6-tetrahydrobenzo[h]cinnolin-2(3H)-yl)propyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;

With sodium hydroxide; In dichloromethane; at 0 ℃;
DOI:10.1039/c3md00095h