1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-(2-trimethylsilylethynyl)benzene

Base Information

• Chemical Name: 1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-(2-trimethylsilylethynyl)benzene
• CAS No.: 333723-85-6
• Molecular Formula: C₃₀H₂₆Cl₂F₂O₅Si
• Molecular Weight: 603.522

Synonyms:1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-(2-trimethylsilylethynyl)benzene

Chemical Property of 1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-(2-trimethylsilylethynyl)benzene

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Technology Process of 1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-(2-trimethylsilylethynyl)benzene

There total 1 articles about 1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-(2-trimethylsilylethynyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-iodobenzene (333447-73-7) + trimethylsilylacetylene (1066-54-2) → 1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-(2-trimethylsilylethynyl)benzene (333723-85-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 25 ℃; for 12h;

DOI:10.1081/NCN-100001436

Reference yield: 97.0%

1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-(2-trimethylsilylethynyl)benzene (333723-85-6) → C27H17Cl2F2IO5

Guidance literature:

With N-iodo-succinimide; silver nitrate; In acetone; at 25 ℃; for 2h;

DOI:10.1081/NCN-100001436

Reference yield: 92.0%

1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-(2-trimethylsilylethynyl)benzene (333723-85-6) → 1-(2-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-ethynylbenzene

Guidance literature:

With sodium methylate; In methanol; at 25 ℃; for 0.5h;

DOI:10.1081/NCN-100001436

upstream raw materials:

1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-iodobenzene

trimethylsilylacetylene

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