C-(5,5-bis-dodecyloxymethyl-[1,3]dithian-2-yl)-C-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-methylamine

Base Information

• Chemical Name: C-(5,5-bis-dodecyloxymethyl-[1,3]dithian-2-yl)-C-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-methylamine
• CAS No.: 438226-86-9
• Molecular Formula: C₄₂H₇₅NO₄S₂
• Molecular Weight: 722.194
• Mol file: 438226-86-9.mol

Synonyms:C-(5,5-bis-dodecyloxymethyl-[1,3]dithian-2-yl)-C-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-methylamine

Chemical Property of C-(5,5-bis-dodecyloxymethyl-[1,3]dithian-2-yl)-C-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-methylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C-(5,5-bis-dodecyloxymethyl-[1,3]dithian-2-yl)-C-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-methylamine

There total 4 articles about C-(5,5-bis-dodecyloxymethyl-[1,3]dithian-2-yl)-C-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-trimethylsilyl-4-(tetrahydro-pyran-2-yloxy)-benzaldimine (438226-84-7) + 5,5-bis-dodecyloxymethyl-[1,3]dithiane (552315-69-2) → C-(5,5-bis-dodecyloxymethyl-[1,3]dithian-2-yl)-C-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-methylamine (438226-86-9)

Guidance literature:

5,5-bis-dodecyloxymethyl-[1,3]dithiane; With n-butyllithium; In tetrahydrofuran; at -25 - -20 ℃; for 2h;

N-trimethylsilyl-4-(tetrahydro-pyran-2-yloxy)-benzaldimine; In tetrahydrofuran; at -20 ℃; Further stages.;

DOI:10.1021/ja016874i

Reference yield:

4-(tetrahydropyran-2-yloxy)benzaldehyde (74189-56-3) → C-(5,5-bis-dodecyloxymethyl-[1,3]dithian-2-yl)-C-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-methylamine (438226-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: n-BuLi / tetrahydrofuran / 2 h / -25 - -20 °C

2.2: 1.73 g / tetrahydrofuran / -20 °C

With n-butyllithium; In tetrahydrofuran;

DOI:10.1021/ja016874i

Reference yield:

1-dodecylbromide (143-15-7) → C-(5,5-bis-dodecyloxymethyl-[1,3]dithian-2-yl)-C-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-methylamine (438226-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide

1.2: dimethylformamide / 20 °C

2.1: n-BuLi / tetrahydrofuran / 2 h / -25 - -20 °C

2.2: 1.73 g / tetrahydrofuran / -20 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja016874i

upstream raw materials:

N-trimethylsilyl-4-(tetrahydro-pyran-2-yloxy)-benzaldimine

5,5-bis-dodecyloxymethyl-[1,3]dithiane

4-(tetrahydropyran-2-yloxy)benzaldehyde

1-dodecylbromide

Downstream raw materials:

{(5,5-bis-dodecyloxymethyl-[1,3]dithian-2-yl)-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-methyl}-(5-nitro-pyridin-2-yl)-amine

4-[(5,5-bis-dodecyloxymethyl-[1,3]dithian-2-yl)-(5-nitro-pyridin-2-ylamino)-methyl]-phenol