(R)-3-[4-((R)-2-Carboxy-1-phenyl-ethylcarbamoyl)-pyridine-2-sulfonylamino]-3-phenyl-propionic acid

Base Information

• Chemical Name: (R)-3-[4-((R)-2-Carboxy-1-phenyl-ethylcarbamoyl)-pyridine-2-sulfonylamino]-3-phenyl-propionic acid
• CAS No.: 100923-36-2
• Molecular Formula: C₂₄H₂₃N₃O₇S
• Molecular Weight: 497.529
• Mol file: 100923-36-2.mol

Synonyms:(R)-3-[4-((R)-2-Carboxy-1-phenyl-ethylcarbamoyl)-pyridine-2-sulfonylamino]-3-phenyl-propionic acid

Chemical Property of (R)-3-[4-((R)-2-Carboxy-1-phenyl-ethylcarbamoyl)-pyridine-2-sulfonylamino]-3-phenyl-propionic acid

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-[4-((R)-2-Carboxy-1-phenyl-ethylcarbamoyl)-pyridine-2-sulfonylamino]-3-phenyl-propionic acid

There total 1 articles about (R)-3-[4-((R)-2-Carboxy-1-phenyl-ethylcarbamoyl)-pyridine-2-sulfonylamino]-3-phenyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

(R)-3-phenyl-3-aminopropionic acid (614-19-7,3646-50-2,13921-90-9,40856-44-8) + isonicotinoyl chloride-2-sulphonyl chloride (100923-31-7) → (R)-3-[4-((R)-2-Carboxy-1-phenyl-ethylcarbamoyl)-pyridine-2-sulfonylamino]-3-phenyl-propionic acid (100923-36-2)

Guidance literature:

With triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide; 0 deg C, 1 h; RT, 3-4 h; RT, overnight;

Reference yield: 91.0%

methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride (5680-80-8) + (R)-3-[4-((R)-2-Carboxy-1-phenyl-ethylcarbamoyl)-pyridine-2-sulfonylamino]-3-phenyl-propionic acid (100923-36-2) → (S)-3-Hydroxy-2-((R)-3-{4-[(R)-2-((S)-2-hydroxy-1-methoxycarbonyl-ethylcarbamoyl)-1-phenyl-ethylcarbamoyl]-pyridine-2-sulfonylamino}-3-phenyl-propionylamino)-propionic acid methyl ester

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; 0 deg C, 2-3 h; RT, 24 h;

Reference yield: 81.0%

L-tyrosine methyl ester HCl (3417-91-2) + (R)-3-[4-((R)-2-Carboxy-1-phenyl-ethylcarbamoyl)-pyridine-2-sulfonylamino]-3-phenyl-propionic acid (100923-36-2) → (S)-3-(4-Hydroxy-phenyl)-2-[(R)-3-(4-{(R)-2-[(S)-2-(4-hydroxy-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-1-phenyl-ethylcarbamoyl}-pyridine-2-sulfonylamino)-3-phenyl-propionylamino]-propionic acid methyl ester

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; 0 deg C, 2-3 h; RT, 24 h;

upstream raw materials:

(R)-3-phenyl-3-aminopropionic acid

isonicotinoyl chloride-2-sulphonyl chloride