(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3-[2-(benzyloxycarbonyl-methyl-amino)-ethyl]-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl ester

Base Information

Chemical Name:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3-[2-(benzyloxycarbonyl-methyl-amino)-ethyl]-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl ester
CAS No.:676451-27-7
Molecular Formula:C₃₀H₂₉F₃N₂O₆
Molecular Weight:570.565
Hs Code.:

Synonyms:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3-[2-(benzyloxycarbonyl-methyl-amino)-ethyl]-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl ester

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Chemical Property of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3-[2-(benzyloxycarbonyl-methyl-amino)-ethyl]-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl ester

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Technology Process of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3-[2-(benzyloxycarbonyl-methyl-amino)-ethyl]-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl ester

There total 4 articles about (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3-[2-(benzyloxycarbonyl-methyl-amino)-ethyl]-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 676451-25-5
[2-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-methyl-carbamic acid benzyl ester

: 676451-29-9
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-3-[2-(benzyloxycarbonyl-methyl-amino)-ethyl]-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl ester

: 676451-27-7
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3-[2-(benzyloxycarbonyl-methyl-amino)-ethyl]-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl ester

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1016/j.tet.2003.11.034

Reference yield:

: 37637-29-9
N-methyl-2-(1-methyl-1H-indol-3-yl)ethan-1-amine

: 676451-27-7
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3-[2-(benzyloxycarbonyl-methyl-amino)-ethyl]-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / Na₂CO₃ / CH₂Cl₂; H₂O / 1 h / 0 °C

2: 71 percent / HCl; DMSO; phenol / acetic acid / 0.17 h / 0 °C

3: 100 percent / O₂; aq. NaOH / tetrahydrofuran / 4 h / 20 °C

4: 43 percent / DMAP / CH₂Cl₂ / 1.5 h / 20 °C

With hydrogenchloride; dmap; sodium hydroxide; oxygen; sodium carbonate; dimethyl sulfoxide; phenol; In tetrahydrofuran; dichloromethane; water; acetic acid;
DOI:10.1016/j.tet.2003.11.034

Reference yield:

: 676451-22-2
Na,Nb-dimethyl-Nb-carbobenzyloxytryptamine

: 676451-27-7
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3-[2-(benzyloxycarbonyl-methyl-amino)-ethyl]-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / HCl; DMSO; phenol / acetic acid / 0.17 h / 0 °C

2: 100 percent / O₂; aq. NaOH / tetrahydrofuran / 4 h / 20 °C

3: 43 percent / DMAP / CH₂Cl₂ / 1.5 h / 20 °C

With hydrogenchloride; dmap; sodium hydroxide; oxygen; dimethyl sulfoxide; phenol; In tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1016/j.tet.2003.11.034