1-Benzyl-3(S)-benzyloxymethylpiperazine-2,5-dione

Base Information

Chemical Name:1-Benzyl-3(S)-benzyloxymethylpiperazine-2,5-dione
CAS No.:169448-85-5
Molecular Formula:C₁₉H₂₀N₂O₃
Molecular Weight:324.379
Hs Code.:
DSSTox Substance ID:DTXSID601163673

Synonyms:SCHEMBL8574805;FXHKCIGMMGPLKQ-KRWDZBQOSA-N;DTXSID601163673;1-Benzyl-3(S)-benzyloxymethylpiperazine-2,5-dione;(3S)-3-[(Phenylmethoxy)methyl]-1-(phenylmethyl)-2,5-piperazinedione;169448-85-5

Suppliers and Price of 1-Benzyl-3(S)-benzyloxymethylpiperazine-2,5-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of 1-Benzyl-3(S)-benzyloxymethylpiperazine-2,5-dione

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:324.14739250
Heavy Atom Count:24
Complexity:428

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(=O)NC(C(=O)N1CC2=CC=CC=C2)COCC3=CC=CC=C3
Isomeric SMILES:C1C(=O)N[C@H](C(=O)N1CC2=CC=CC=C2)COCC3=CC=CC=C3

Technology Process of 1-Benzyl-3(S)-benzyloxymethylpiperazine-2,5-dione

There total 5 articles about 1-Benzyl-3(S)-benzyloxymethylpiperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [((S)-2-Amino-3-benzyloxy-propionyl)-benzyl-amino]-acetic acid ethyl ester

: 169448-85-5
1-benzyl-3-benzyloxymethyl-2,5-diketopiperazine

Guidance literature:: With TEA; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm990337f

Reference yield:

: 6436-90-4
ethyl 2-(benzylamino)acetate

: 169448-85-5
1-benzyl-3-benzyloxymethyl-2,5-diketopiperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 80.6 percent / HOBT; dicyclohexylcarbodiimide / CH₂Cl₂ / 0 - 20 °C

2: TFA / CH₂Cl₂ / 1 h / 20 °C

3: TEA / CH₂Cl₂ / 2 h / 20 °C

With TEA; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; 1: Condensation / 2: Deprotection / 3: Cyclization;
DOI:10.1021/jm990337f

Reference yield:

: 23680-31-1
BOC-O-benzyl-L-serine

: 169448-85-5
1-benzyl-3-benzyloxymethyl-2,5-diketopiperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 80.6 percent / HOBT; dicyclohexylcarbodiimide / CH₂Cl₂ / 0 - 20 °C

2: TFA / CH₂Cl₂ / 1 h / 20 °C

3: TEA / CH₂Cl₂ / 2 h / 20 °C

With TEA; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; 1: Condensation / 2: Deprotection / 3: Cyclization;
DOI:10.1021/jm990337f