2-({[(2-fluoro-5-nitrophenyl)methyl]prop-2-enylamino}methyl)phenol

Base Information

• Chemical Name: 2-({[(2-fluoro-5-nitrophenyl)methyl]prop-2-enylamino}methyl)phenol
• CAS No.: 278594-26-6
• Molecular Formula: C₁₇H₁₇FN₂O₃
• Molecular Weight: 316.332
• Mol file: 278594-26-6.mol

Synonyms:2-({[(2-fluoro-5-nitrophenyl)methyl]prop-2-enylamino}methyl)phenol

Chemical Property of 2-({[(2-fluoro-5-nitrophenyl)methyl]prop-2-enylamino}methyl)phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-({[(2-fluoro-5-nitrophenyl)methyl]prop-2-enylamino}methyl)phenol

There total 2 articles about 2-({[(2-fluoro-5-nitrophenyl)methyl]prop-2-enylamino}methyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-methyl-benzyl alcohol (89-95-2) + [(2-fluoro-5-nitrophenyl)methyl]prop-2-enylamine (278594-24-4) → 2-({[(2-fluoro-5-nitrophenyl)methyl]prop-2-enylamino}methyl)phenol (278594-26-6)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; trimethyl orthoformate; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/S0040-4020(00)00120-4

Reference yield:

2-fluoro-5-nitrobenzaldehye (27996-87-8) → 2-({[(2-fluoro-5-nitrophenyl)methyl]prop-2-enylamino}methyl)phenol (278594-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / NaBH(OAc)3; AcOH; CH(OMe)3 / toluene / 6 h / 20 °C

2: 80 percent / NaBH(OAc)3; AcOH; CH(OMe)3 / CH₂Cl₂ / 18 h / 20 °C

With sodium tris(acetoxy)borohydride; acetic acid; trimethyl orthoformate; In dichloromethane; toluene; 1: Reductive amination / 2: Reductive amination;

DOI:10.1016/S0040-4020(00)00120-4

upstream raw materials:

2-methyl-benzyl alcohol

[(2-fluoro-5-nitrophenyl)methyl]prop-2-enylamine

2-fluoro-5-nitrobenzaldehye