(S)-1-{5-[N-(methoxymethyl)-1H-indol-3-yl]oxazol-2-yl}-2-phenylethanamine

Base Information

• Chemical Name: (S)-1-{5-[N-(methoxymethyl)-1H-indol-3-yl]oxazol-2-yl}-2-phenylethanamine
• CAS No.: 935261-51-1
• Molecular Formula: C₂₁H₂₁N₃O₂
• Molecular Weight: 347.417
• Mol file: 935261-51-1.mol

Synonyms:(S)-1-{5-[N-(methoxymethyl)-1H-indol-3-yl]oxazol-2-yl}-2-phenylethanamine

Chemical Property of (S)-1-{5-[N-(methoxymethyl)-1H-indol-3-yl]oxazol-2-yl}-2-phenylethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-{5-[N-(methoxymethyl)-1H-indol-3-yl]oxazol-2-yl}-2-phenylethanamine

There total 5 articles about (S)-1-{5-[N-(methoxymethyl)-1H-indol-3-yl]oxazol-2-yl}-2-phenylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-[(S)-1-{5-[N-(methoxymethyl)-1H-indol-3-yl]oxazol-2-yl}-2-phenylethyl]isoindoline-1,3-dione (935261-50-0) → (S)-1-{5-[N-(methoxymethyl)-1H-indol-3-yl]oxazol-2-yl}-2-phenylethanamine (935261-51-1)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 36h;

DOI:10.1055/s-2007-967995

Reference yield:

1-(1-methoxymethyl-1H-indol-3-yl)-ethanone (935261-43-1) → (S)-1-{5-[N-(methoxymethyl)-1H-indol-3-yl]oxazol-2-yl}-2-phenylethanamine (935261-51-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 90 percent / benzyltrimethyl-ammonium dichloroiodate / 120 h / 20 °C

2.1: 77 percent / sodium azide / acetone; H₂O / 18 h / Heating

3.1: tetrahydrofuran / 0 °C

3.2: 70 percent / Et₃N / tetrahydrofuran / 2 h / 20 °C

4.1: 90 percent / hydrazine monohydrate / ethanol / 36 h / 20 °C

With sodium azide; N,N,N-trimethylbenzenemethanaminium dichloroiodate; hydrazine hydrate; In tetrahydrofuran; ethanol; water; acetone; 3.1: aza-Wittig reaction;

DOI:10.1055/s-2007-967995

Reference yield:

2-chloro-1-(1-methoxymethyl-1H-indol-3-yl)-ethanone (935261-45-3) → (S)-1-{5-[N-(methoxymethyl)-1H-indol-3-yl]oxazol-2-yl}-2-phenylethanamine (935261-51-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 77 percent / sodium azide / acetone; H₂O / 18 h / Heating

2.1: tetrahydrofuran / 0 °C

2.2: 70 percent / Et₃N / tetrahydrofuran / 2 h / 20 °C

3.1: 90 percent / hydrazine monohydrate / ethanol / 36 h / 20 °C

With sodium azide; hydrazine hydrate; In tetrahydrofuran; ethanol; water; acetone; 2.1: aza-Wittig reaction;

DOI:10.1055/s-2007-967995

upstream raw materials:

2-[(S)-1-{5-[N-(methoxymethyl)-1H-indol-3-yl]oxazol-2-yl}-2-phenylethyl]isoindoline-1,3-dione

1-(1-methoxymethyl-1H-indol-3-yl)-ethanone

2-chloro-1-(1-methoxymethyl-1H-indol-3-yl)-ethanone

N-methoxymethyl-3-azidoacetylindole