(R)-3-((S)-1-(4'-fluorobiphenyl-4-yl)propyl)-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one

Base Information

Chemical Name:(R)-3-((S)-1-(4'-fluorobiphenyl-4-yl)propyl)-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one
CAS No.:1114085-85-6
Molecular Formula:C₂₈H₃₀FNO₃
Molecular Weight:447.55
Hs Code.:

Synonyms:(R)-3-((S)-1-(4'-fluorobiphenyl-4-yl)propyl)-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one

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Chemical Property of (R)-3-((S)-1-(4'-fluorobiphenyl-4-yl)propyl)-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one

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Technology Process of (R)-3-((S)-1-(4'-fluorobiphenyl-4-yl)propyl)-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one

There total 5 articles about (R)-3-((S)-1-(4'-fluorobiphenyl-4-yl)propyl)-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1321599-87-4
(R)-6-allyl-3-((S)-1-(4'-fluoro-[1,1'-biphenyl]-4-yl)propyl)-6-phenyl-1,3-oxazinan-2-one

: 1114085-85-6
(R)-3-((S)-1-(4'-fluorobiphenyl-4-yl)propyl)-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one

Guidance literature:: (R)-6-allyl-3-((S)-1-(4'-fluoro-[1,1'-biphenyl]-4-yl)propyl)-6-phenyl-1,3-oxazinan-2-one; With borane; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 2h;
DOI:10.1021/jm2005354

Reference yield:

: 1110641-90-1
(R)-6-allyl-3-((S)-1-(4-bromophenyl)propyl)-6-phenyl-1,3-oxazinan-2-one

: 1114085-85-6
(R)-3-((S)-1-(4'-fluorobiphenyl-4-yl)propyl)-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / tetrahydrofuran; water / Inert atmosphere; Reflux

2.1: borane / tetrahydrofuran / 2 h / 0 - 20 °C

2.2: 2 h / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; borane; sodium carbonate; In tetrahydrofuran; water; 1.1: Suzuki coupling;
DOI:10.1021/jm2005354

Reference yield:

: 1114065-37-0
(S)-4-BrC₆H₄CHEtNCO

: 1114085-85-6
(R)-3-((S)-1-(4'-fluorobiphenyl-4-yl)propyl)-6-(3-hydroxypropyl)-6-phenyl-1,3-oxazinan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / Reflux

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / tetrahydrofuran; water / Inert atmosphere; Reflux

3.1: borane / tetrahydrofuran / 2 h / 0 - 20 °C

3.2: 2 h / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; borane; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; water; 2.1: Suzuki coupling;
DOI:10.1021/jm2005354