CIS-3,4-DIMETHYLCYCLOHEXANONE

Base Information

• Chemical Name: CIS-3,4-DIMETHYLCYCLOHEXANONE
• CAS No.: 27922-05-0
• Molecular Formula: C8H14 O
• Molecular Weight: 126.199
• Hs Code.: 2914299000
• Mol file: 27922-05-0.mol

Synonyms:Cyclohexanone,3,4-dimethyl-, cis- (8CI); (?à)-cis-3,4-Dimethylcyclohexanone; cis-3,4-Dimethylcyclohexanone

Chemical Property of CIS-3,4-DIMETHYLCYCLOHEXANONE

Chemical Property:

• PSA: 17.07000
• LogP: 2.01160

Purity/Quality:

99% ^*data from raw suppliers

cis-3,4-Dimethylcyclohexanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CIS-3,4-DIMETHYLCYCLOHEXANONE

There total 30 articles about CIS-3,4-DIMETHYLCYCLOHEXANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1,2-trans-dimethylcyclohexane (6876-23-9) → 1,2-dimethylcyclohexanol (19879-11-9) + trans-2,3-dimethylcyclohexanone (1551-89-9) + trans-1,2-dimethyl-cyclohexan-4-one (5465-09-8,27922-05-0,28023-45-2,69127-34-0,75364-86-2,75364-88-4,75364-89-5,113348-79-1)

Guidance literature:

With methyltrifluoromethyldioxirane; In dichloromethane; at -22 ℃; for 0.166667h; Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00199a039

Reference yield: 75.0%

4-methyl-2-cyclohexenone (75337-05-2,79980-78-2,101758-35-4,5515-76-4) + methyllithium (917-54-4) → trans-1,2-dimethyl-cyclohexan-4-one (5465-09-8,27922-05-0,28023-45-2,69127-34-0,75364-86-2,75364-88-4,75364-89-5,113348-79-1)

Guidance literature:

methyllithium; With copper(l) cyanide; In diethyl ether; at -78 - 0 ℃; Inert atmosphere;

4-methyl-2-cyclohexenone; In diethyl ether; at -78 ℃; Inert atmosphere;

With water; ammonium chloride; In diethyl ether; Inert atmosphere;

DOI:10.1002/anie.201304359

Reference yield:

cis-1,2-dimethylcyclohexane (2207-01-4) → cis-1,2-dimethylcyclohexanol (19879-12-0) + 1,2-dimethylcyclohexanol (19879-11-9) + cis-2,3-dimethylcyclohexanone (1551-88-8) + cis-1,2-dimethyl-cyclohexan-4-one (27922-05-0) + 2-Methylcyclohexanone (583-60-8)

Guidance literature:

With oxygen; silica gel; ozone; for 0.5h; Product distribution; Mechanism; -78 deg C to r.t.;

upstream raw materials:

trans-4,5-dimethylcyclohexene

3,4-dimethylcyclohexanone

1,2-trans-dimethylcyclohexane

trans-3,4-dimethylcyclohexene

Downstream raw materials:

cis-1,2-dimethylcyclohexane

1,2-trans-dimethylcyclohexane

1-phenyl-t-3,c-4-dimethylcyclohexan-r-1-ol

1-phenyl-t-3,c-4-dimethylcyclohexan-r-1-ol