(3R,4S)-4-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2-dimethyl-6-nitrochroman-3-ol

Base Information

Chemical Name:(3R,4S)-4-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2-dimethyl-6-nitrochroman-3-ol
CAS No.:1353562-39-6
Molecular Formula:C₂₂H₂₇N₃O₅
Molecular Weight:413.473
Hs Code.:

Synonyms:(3R,4S)-4-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2-dimethyl-6-nitrochroman-3-ol

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Chemical Property of (3R,4S)-4-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2-dimethyl-6-nitrochroman-3-ol

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Technology Process of (3R,4S)-4-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2-dimethyl-6-nitrochroman-3-ol

There total 2 articles about (3R,4S)-4-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2-dimethyl-6-nitrochroman-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 38212-30-5
4-(4-methoxyphenyl)piperazine

: 58740-90-2,68196-67-8,134176-47-9,134176-48-0
(3R,4R)-3,4-epoxy-2,2-dimethyl-6-nitrochromane

: 1353562-39-6
(3R,4S)-4-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2-dimethyl-6-nitrochroman-3-ol

Guidance literature:: With aluminum oxide; In butan-1-ol; at 117 ℃; for 0.2h; stereoselective reaction; Microwave irradiation; Green chemistry;
DOI:10.1016/j.tetasy.2012.07.002

Reference yield:

: 33143-28-1
6-nitro-2,2-dimethyl chromene

: 1353562-39-6
(3R,4S)-4-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2-dimethyl-6-nitrochroman-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: (-)-chloro((1R,2R)-4,4',6,6'-tetra-tert-butyl-2,2'-[cyclohexane-1,2-diylbis(nitrilomethylidyne)]diphenolato)manganese(III); sodium hypochlorite; sodium phosphate dibasic dodecahydrate / dichloromethane

2: aluminum oxide / butan-1-ol / 0.2 h / 117 °C / Microwave irradiation; Green chemistry

With aluminum oxide; sodium hypochlorite; sodium phosphate dibasic dodecahydrate; (-)-chloro((1R,2R)-4,4',6,6'-tetra-tert-butyl-2,2'-[cyclohexane-1,2-diylbis(nitrilomethylidyne)]diphenolato)manganese(III); In dichloromethane; butan-1-ol;
DOI:10.1016/j.tetasy.2012.07.002