N-(4-methoxycarbonylphenyl)-3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionamide

Base Information

Chemical Name:N-(4-methoxycarbonylphenyl)-3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionamide
CAS No.:652538-77-7
Molecular Formula:C₂₃H₂₂N₆O₃
Molecular Weight:430.466
Hs Code.:

Synonyms:N-(4-methoxycarbonylphenyl)-3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionamide

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Chemical Property of N-(4-methoxycarbonylphenyl)-3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionamide

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Technology Process of N-(4-methoxycarbonylphenyl)-3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionamide

There total 8 articles about N-(4-methoxycarbonylphenyl)-3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 652538-76-6
3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionic acid

: 619-45-4
4-methoxycarbonyl aniline

: 652538-77-7
N-(4-methoxycarbonylphenyl)-3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1055/s-2006-958963

Reference yield: 78.0%

: 619-45-4
4-methoxycarbonyl aniline

: 652538-77-7
N-(4-methoxycarbonylphenyl)-3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionamide

Guidance literature:: 3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionic acid; With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

4-methoxycarbonyl aniline; In N,N-dimethyl-formamide; for 48h;

Reference yield:

: tert-butyl 3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]prop-2-enoate

: 652538-77-7
N-(4-methoxycarbonylphenyl)-3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / H₂ / Pd/C / tetrahydrofuran; ethyl acetate / 6 h / 20 °C / 7500.75 Torr

2: 87 percent / TFA / toluene / 4 h / 20 °C

3: 95 percent / DMAP; EDCl / CH₂Cl₂ / 24 h / 20 °C

With dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene;
DOI:10.1055/s-2006-958963