N-(3-Azidopropyl)biotinaMide

Base Information

• Chemical Name: N-(3-Azidopropyl)biotinaMide
• CAS No.: 908007-17-0
• Molecular Formula: C₁₃H₂₂N₆O₂S
• Molecular Weight: 326.423
• Mol file: 908007-17-0.mol

Synonyms:N-(3-azidopropyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

Chemical Property of N-(3-Azidopropyl)biotinaMide

Chemical Property:

• Melting Point: 166.0 to 170.0 °C
• Boiling Point: No Data Availablemg

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(3-Azidopropyl)biotinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-(3-Azidopropyl)biotinamide is used as a reactant in the synthesis of clickable coumarins as fluorescent labels for amino acids.

Technology Process of N-(3-Azidopropyl)biotinaMide

There total 5 articles about N-(3-Azidopropyl)biotinaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.7%

3-azidopropylamine (88192-19-2) + biotin (58-85-5,22879-79-4) → N-(3-azidopropyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide (908007-17-0)

Guidance literature:

biotin; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 25 ℃; for 3h;

3-azidopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 12.5h;

DOI:10.1002/asia.201100489

Reference yield: 83.0%

3-azidopropylamine (88192-19-2) + biotin N-Hydroxysuccinimide ester (35013-72-0) → N-(3-azidopropyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide (908007-17-0)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1002/anie.200600756

Reference yield: 82.0%

3-azidopropylamide + biotin N-Hydroxysuccinimide ester (35013-72-0) → N-(3-azidopropyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide (908007-17-0)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1002/anie.201306295

upstream raw materials:

3-azidopropylamine

biotin N-Hydroxysuccinimide ester

biotin

3-azidopropan-1-ol