phenyl (S)-5-benzyloxy-3-hydroxy-4,4-dimethylpentanoate

Base Information

• Chemical Name: phenyl (S)-5-benzyloxy-3-hydroxy-4,4-dimethylpentanoate
• CAS No.: 224968-18-7
• Molecular Formula: C₂₀H₂₄O₄
• Molecular Weight: 328.408
• Mol file: 224968-18-7.mol

Synonyms:phenyl (S)-5-benzyloxy-3-hydroxy-4,4-dimethylpentanoate

Chemical Property of phenyl (S)-5-benzyloxy-3-hydroxy-4,4-dimethylpentanoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of phenyl (S)-5-benzyloxy-3-hydroxy-4,4-dimethylpentanoate

There total 1 articles about phenyl (S)-5-benzyloxy-3-hydroxy-4,4-dimethylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(S)-5-Benzyloxy-3-hydroxy-4,4-dimethyl-1-phenyl-pentan-1-one (212050-32-3) → phenyl (S)-5-benzyloxy-3-hydroxy-4,4-dimethylpentanoate (224968-18-7)

Guidance literature:

With sodium dihydrogenphosphate; 3-chloro-benzenecarboperoxoic acid; In 1,2-dichloro-ethane; at 40 ℃; for 50h;

DOI:10.1021/ja990031y

Reference yield: 99.0%

phenyl (S)-5-benzyloxy-3-hydroxy-4,4-dimethylpentanoate (224968-18-7) → (3S)-1-benzyloxy-2,2-dimethylpentane-3,5-diol (152426-81-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 0.75h;

DOI:10.1021/ja990031y

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) + phenyl (S)-5-benzyloxy-3-hydroxy-4,4-dimethylpentanoate (224968-18-7) → 5-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyl-pentanoic acid phenyl ester (224968-24-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.75h;

DOI:10.1021/ja990031y

upstream raw materials:

(S)-5-Benzyloxy-3-hydroxy-4,4-dimethyl-1-phenyl-pentan-1-one

Downstream raw materials:

5-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyl-pentanoic acid phenyl ester

(3S)-1-benzyloxy-2,2-dimethylpentane-3,5-diol

2-<(4R,6S)-6-(2-benzyloxy-1,1-dimethylethyl)-2,2-dimethyl-1,3-dioxan-4-yl>ethanol

(4S)-4-(2-benzyloxy-1,1-dimethylethyl)-2,2-dimethyl[1,3]dioxane