3-(R)-amino-2-(S)-[(4'-ethylbiphenyl-4-carbonyl)amino]butyric acid methyl ester

Base Information

Chemical Name:3-(R)-amino-2-(S)-[(4'-ethylbiphenyl-4-carbonyl)amino]butyric acid methyl ester
CAS No.:728878-02-2
Molecular Formula:C₂₀H₂₄N₂O₃
Molecular Weight:340.422
Hs Code.:

Synonyms:3-(R)-amino-2-(S)-[(4'-ethylbiphenyl-4-carbonyl)amino]butyric acid methyl ester

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Chemical Property of 3-(R)-amino-2-(S)-[(4'-ethylbiphenyl-4-carbonyl)amino]butyric acid methyl ester

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Technology Process of 3-(R)-amino-2-(S)-[(4'-ethylbiphenyl-4-carbonyl)amino]butyric acid methyl ester

There total 1 articles about 3-(R)-amino-2-(S)-[(4'-ethylbiphenyl-4-carbonyl)amino]butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5731-13-5
4-(4-ethylphenyl)benzoic acid

: 728878-02-2
3-(R)-amino-2-(S)-[(4'-ethylbiphenyl-4-carbonyl)amino]butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 120 °C / 760.05 Torr / Sonication; Inert atmosphere

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

Reference yield:

: 728878-02-2
3-(R)-amino-2-(S)-[(4'-ethylbiphenyl-4-carbonyl)amino]butyric acid methyl ester

: 59701-84-7
4-(2-chloroacetyl)-piperazin-2-one

: methyl (2S,3R)-2-(4'-ethyl-[1,1'-biphenyl]-4-carboxamido)-3-(((3-oxopiperazin-1-yl)oxoethyl)amino)butanoate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 36h;
DOI:10.1021/acs.jmedchem.7b00377

Reference yield:

: 728878-02-2
3-(R)-amino-2-(S)-[(4'-ethylbiphenyl-4-carbonyl)amino]butyric acid methyl ester

: 59701-84-7
4-(2-chloroacetyl)-piperazin-2-one

: 4'-ethyl-N-((2S,3R)-1-(hydroxyamino)-1-oxo-3-(((3-oxopiperazin-1-yl)oxoethyl)amino)butan-2-yl)-[1,1'-biphenyl]-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 36 h / 50 °C

2: hydroxylamine / methanol / 48 h / 20 °C

With hydroxylamine; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.7b00377