1-(2-hydroxyethyl)-1-(3-methoxybenzyl)-3-[4-(1H-pyrazol-4-yl)phenyl]urea

Base Information

Chemical Name:1-(2-hydroxyethyl)-1-(3-methoxybenzyl)-3-[4-(1H-pyrazol-4-yl)phenyl]urea
CAS No.:1219722-68-5
Molecular Formula:C₂₀H₂₂N₄O₃
Molecular Weight:366.42
Hs Code.:

Synonyms:1-(2-hydroxyethyl)-1-(3-methoxybenzyl)-3-[4-(1H-pyrazol-4-yl)phenyl]urea

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Chemical Property of 1-(2-hydroxyethyl)-1-(3-methoxybenzyl)-3-[4-(1H-pyrazol-4-yl)phenyl]urea

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Technology Process of 1-(2-hydroxyethyl)-1-(3-methoxybenzyl)-3-[4-(1H-pyrazol-4-yl)phenyl]urea

There total 9 articles about 1-(2-hydroxyethyl)-1-(3-methoxybenzyl)-3-[4-(1H-pyrazol-4-yl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-{4-[3-(2-hydroxyethyl)-3-(3-methoxybenzyl)ureido]phenyl}pyrazole-1-carboxylic acid tert-butyl ester

: 1219722-68-5
1-(2-hydroxyethyl)-1-(3-methoxybenzyl)-3-[4-(1H-pyrazol-4-yl)phenyl]urea

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 0 - 65 ℃; for 1h; Inert atmosphere;

Reference yield:

: 269410-08-4
pyrazole-4-boronic acid pinacol ester

: 1219729-13-1
3-(4-bromophenyl)-1-(2-hydroxyethyl)-1-(3-methoxybenzyl)urea

: 1219722-68-5
1-(2-hydroxyethyl)-1-(3-methoxybenzyl)-3-[4-(1H-pyrazol-4-yl)phenyl]urea

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 95 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm400062r

Reference yield:

: 64834-62-4
2-((3-methoxyphenyl)amino)ethane-1-ol

: 1219722-68-5
1-(2-hydroxyethyl)-1-(3-methoxybenzyl)-3-[4-(1H-pyrazol-4-yl)phenyl]urea

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 2 h / 95 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; dichloromethane; water; 2: |Suzuki Coupling;
DOI:10.1021/jm400062r