N-<(diethylphosphono)acetyl>-7-amino-3,5-O-(R)-benzylidene-6,7-dideoxy-1,2-O-isopropylidene-α-D-gluco-hepto-1,4-furanose

Base Information

Chemical Name:N-<(diethylphosphono)acetyl>-7-amino-3,5-O-(R)-benzylidene-6,7-dideoxy-1,2-O-isopropylidene-α-D-gluco-hepto-1,4-furanose
CAS No.:136839-44-6
Molecular Formula:C₂₃H₃₄NO₉P
Molecular Weight:499.498
Hs Code.:

Synonyms:N-<(diethylphosphono)acetyl>-7-amino-3,5-O-(R)-benzylidene-6,7-dideoxy-1,2-O-isopropylidene-α-D-gluco-hepto-1,4-furanose

Suppliers and Price of N-<(diethylphosphono)acetyl>-7-amino-3,5-O-(R)-benzylidene-6,7-dideoxy-1,2-O-isopropylidene-α-D-gluco-hepto-1,4-furanose

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-<(diethylphosphono)acetyl>-7-amino-3,5-O-(R)-benzylidene-6,7-dideoxy-1,2-O-isopropylidene-α-D-gluco-hepto-1,4-furanose

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-<(diethylphosphono)acetyl>-7-amino-3,5-O-(R)-benzylidene-6,7-dideoxy-1,2-O-isopropylidene-α-D-gluco-hepto-1,4-furanose

There total 6 articles about N-<(diethylphosphono)acetyl>-7-amino-3,5-O-(R)-benzylidene-6,7-dideoxy-1,2-O-isopropylidene-α-D-gluco-hepto-1,4-furanose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 3095-95-2
diethylphosphonoacetic acid

: 136839-43-5
2-((3aR,3bS,5R,7R,7aR,8aR)-2,2-Dimethyl-5-phenyl-tetrahydro-[1,3]dioxolo[4,5]furo[3,2-d][1,3]dioxin-7-yl)-ethylamine

: 136839-44-6
N-<(diethylphosphono)acetyl>-7-amino-3,5-O-(R)-benzylidene-6,7-dideoxy-1,2-O-isopropylidene-α-D-gluco-hepto-1,4-furanose

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In dichloromethane; at 21 ℃; for 8h;
DOI:10.1021/jo00025a033

Reference yield:

: 111056-67-8
3,5-O-(S)-benzylidene-6-deoxy-6-iodo-1,2-O-isopropylidene-α-D-glucofuranose

: 136839-44-6
N-<(diethylphosphono)acetyl>-7-amino-3,5-O-(R)-benzylidene-6,7-dideoxy-1,2-O-isopropylidene-α-D-gluco-hepto-1,4-furanose

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / dimethylformamide / 2 h / 8 °C

2: 99 percent / di(isobutylaluminum hydride / CH₂Cl₂ / 0.92 h / -40 °C

3: 98 percent / NaBH₄ / methanol / 0.33 h / 21 °C

4: 87 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 1.5 h / 21 °C

5: 1.17 g / 80percent hydrazine hydrate / ethanol / 1.5 h / Heating

6: 82 percent / dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate / CH₂Cl₂ / 8 h / 21 °C

With sodium tetrahydroborate; diisobutylaluminium hydride; hydrazine hydrate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00025a033

Reference yield:

: 136839-41-3
3,5-O-(R)-benzylidene-6-deoxy-1,2-O-isopropylidene-α-D-gluco-hepto-1,4-furanose

: 136839-44-6
N-<(diethylphosphono)acetyl>-7-amino-3,5-O-(R)-benzylidene-6,7-dideoxy-1,2-O-isopropylidene-α-D-gluco-hepto-1,4-furanose

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 1.5 h / 21 °C

2: 1.17 g / 80percent hydrazine hydrate / ethanol / 1.5 h / Heating

3: 82 percent / dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate / CH₂Cl₂ / 8 h / 21 °C

With hydrazine hydrate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo00025a033