N-(2-bromo-4-fluorophenyl)-2-methoxybenzamide

Base Information

• Chemical Name: N-(2-bromo-4-fluorophenyl)-2-methoxybenzamide
• CAS No.: 1021439-52-0
• Molecular Formula: C₁₄H₁₁BrFNO₂
• Molecular Weight: 324.149
• Mol file: 1021439-52-0.mol

Synonyms:N-(2-bromo-4-fluorophenyl)-2-methoxybenzamide

Chemical Property of N-(2-bromo-4-fluorophenyl)-2-methoxybenzamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-(2-Bromo-4-fluorophenyl)-2-methoxybenzamide, 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-bromo-4-fluorophenyl)-2-methoxybenzamide

There total 2 articles about N-(2-bromo-4-fluorophenyl)-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-bromo-4-fluoroaniline (1003-98-1) + 2-Methoxybenzoyl chloride (21615-34-9) → N-(2-bromo-4-fluorophenyl)-2-methoxybenzamide (1021439-52-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/jm800418z

Reference yield:

2-bromo-4-fluoroaniline (1003-98-1) + 2-Methoxybenzoyl chloride (21615-34-9) → 2-(2-methoxyphenyl)-6-fluorobenzoxazole (1021439-32-6) + N-(2-bromo-4-fluorophenyl)-2-methoxybenzamide (1021439-52-0)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In acetonitrile; at 170 ℃; for 0.0833333h; microwave irradiation;

DOI:10.1021/jo702145d

Reference yield: 87.0%

N-(2-bromo-4-fluorophenyl)-2-methoxybenzamide (1021439-52-0) → 2-(2-methoxyphenyl)-6-fluorobenzoxazole (1021439-32-6)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In 1,2-dimethoxyethane; for 18h; Reflux; Inert atmosphere;

DOI:10.1021/jm800418z

upstream raw materials:

2-bromo-4-fluoroaniline

2-Methoxybenzoyl chloride

Downstream raw materials:

2-(2-methoxyphenyl)-6-fluorobenzoxazole

Refernces

• 1、 Aiello, Stefania,Wells, Geoffrey,Stone, Erica L.,Kadri, Hachemi,Bazzi, Rana,Bell, David R.,Stevens, Malcolm F. G.,Matthews, Charles S.,Bradshaw, Tracey D.,Westwell, Andrew D.. "Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2-(3,4-dimethoxyphenyl)-5- fluorobenzothiazole (PMX 610, NSC 721648)". supporting information; experimental part. p. 5135 - 5139. Retrieved 2009/08/09.