(S)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid tert-butyl ester

Base Information

Chemical Name:(S)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid tert-butyl ester
CAS No.:404868-04-8
Molecular Formula:C₆₄H₈₈O₉Si
Molecular Weight:1029.48
Hs Code.:

(S)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid tert-butyl ester

Synonyms:(S)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid tert-butyl ester

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Chemical Property of (S)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid tert-butyl ester

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Technology Process of (S)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid tert-butyl ester

There total 11 articles about (S)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 404868-03-7
(S)-3-((2R,3R,4S,5R,6R)-6-Acetoxymethyl-3,4,5-tris-benzyloxy-tetrahydro-pyran-2-yloxy)-17-(tert-butyl-diphenyl-silanyloxy)-heptadecanoic acid tert-butyl ester

: 404868-04-8
(S)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid tert-butyl ester

Guidance literature:: With ammonia; In methanol;
DOI:10.1021/ja0175791 DOI:10.1021/ja036521e

Reference yield:

: 106-02-5,81031-90-5
pentadecanolide

: 404868-04-8
(S)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 61 percent / hexane; tetrahydrofuran / 2 h / -40 °C

2.1: [RuCl₂(COD)]n; H₂; Et₃N / (S)-BINAP / methanol; tetrahydrofuran / 15 h / 70 °C / 11400 Torr

3.1: imidazole / dimethylformamide / 20 °C

4.1: 63 percent / TMSOTf / CH₂Cl₂; acetonitrile / 0.5 h / -50 °C

5.1: 83 percent / NH₃ / methanol

With 1H-imidazole; trimethylsilyl trifluoromethanesulfonate; [RuCl₂(COD)]n; ammonia; hydrogen; triethylamine; lithium diisopropyl amide; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja036521e

Reference yield:

: 404867-95-4
17-hydroxy-3-oxo-heptadecanoic acid tert-butyl ester

: 404868-04-8
(S)-17-(tert-Butyl-diphenyl-silanyloxy)-3-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-heptadecanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: [RuCl₂(COD)]n; H₂; Et₃N / (S)-BINAP / methanol; tetrahydrofuran / 15 h / 70 °C / 11400 Torr

2: imidazole / dimethylformamide / 20 °C

3: 63 percent / TMSOTf / CH₂Cl₂; acetonitrile / 0.5 h / -50 °C

4: 83 percent / NH₃ / methanol

With 1H-imidazole; trimethylsilyl trifluoromethanesulfonate; [RuCl₂(COD)]n; ammonia; hydrogen; triethylamine; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja036521e