6-fluoro-3-((S)-3-triisopropylsilanyloxy-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridine

Base Information

Chemical Name:6-fluoro-3-((S)-3-triisopropylsilanyloxy-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridine
CAS No.:1443244-13-0
Molecular Formula:C₂₀H₃₃FN₄OSi
Molecular Weight:392.592
Hs Code.:

Synonyms:6-fluoro-3-((S)-3-triisopropylsilanyloxy-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridine

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Chemical Property of 6-fluoro-3-((S)-3-triisopropylsilanyloxy-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridine

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Technology Process of 6-fluoro-3-((S)-3-triisopropylsilanyloxy-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridine

There total 1 articles about 6-fluoro-3-((S)-3-triisopropylsilanyloxy-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1443244-12-9
(S)-1-(6-fluoro-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-piperidin-3-ol

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 1443244-13-0
6-fluoro-3-((S)-3-triisopropylsilanyloxy-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridine

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1443244-13-0
6-fluoro-3-((S)-3-triisopropylsilanyloxy-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridine

: 1443244-15-2
1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-((S)-3-triisopropylsilanyloxy-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C

1.2: 0.75 h / 60 - 150 °C

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 3 h / 90 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1443244-13-0
6-fluoro-3-((S)-3-triisopropylsilanyloxy-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridine

: 1443240-34-3
1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-((S)-3-hydroxy-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C

1.2: 0.75 h / 60 - 150 °C

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 3 h / 90 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;